IGF2BP1

Insulin-like growth factor 2 mRNA binding protein 1

Identifiers

IGF2BP1; CRD-BP; CRDBP; IMP-1; IMP1; VICKZ1; ZBP1

External IDs

OMIM: 608288 MGI: 1890357 HomoloGene: 4772 GeneCards: IGF2BP1 Gene

Gene Ontology
Molecular function	• nucleotide binding • mRNA binding • mRNA 3'-UTR binding • protein binding • translation regulator activity • mRNA 5'-UTR binding
Cellular component	• nucleus • nucleolus • cytoplasm • cytosol • plasma membrane • stress granule • lamellipodium • ribonucleoprotein complex • dendritic spine • intracellular membrane-bounded organelle • CRD-mediated mRNA stability complex
Biological process	• RNA localization • regulation of mRNA stability involved in response to stress • negative regulation of translation • regulation of cytokine biosynthetic process • CRD-mediated mRNA stabilization
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
47.07 – 47.13 Mb

Chr 11:
95.82 – 95.87 Mb

PubMed search

[1]

[2]

Insulin-like growth factor 2 mRNA-binding protein 1 is a protein that in humans is encoded by the IGF2BP1 gene.^[1]^[2]^[3]

This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation.^[3]

References

^ Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC (Feb 1999). "A Family of Insulin-Like Growth Factor II mRNA-Binding Proteins Represses Translation in Late Development". Mol Cell Biol 19 (2): 1262–70. PMC 116055. PMID 9891060. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=116055.
^ Yaniv K, Yisraeli JK (May 2002). "The involvement of a conserved family of RNA binding proteins in embryonic development and carcinogenesis". Gene 287 (1–2): 49–54. doi:10.1016/S0378-1119(01)00866-6. PMID 11992722.
^ ^a ^b "Entrez Gene: IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10642.

Yisraeli JK (2005). "VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins". Biol. Cell 97 (1): 87–96. doi:10.1042/BC20040151. PMID 15601260.
Prokipcak RD, Herrick DJ, Ross J (1994). "Purification and properties of a protein that binds to the C-terminal coding region of human c-myc mRNA". J. Biol. Chem. 269 (12): 9261–9. PMID 8132663.
Doyle GA, Betz NA, Leeds PF et al. (1999). "The c-myc coding region determinant-binding protein: a member of a family of KH domain RNA-binding proteins". Nucleic Acids Res. 26 (22): 5036–44. doi:10.1093/nar/26.22.5036. PMC 147974. PMID 9801297. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=147974.
Runge S, Nielsen FC, Nielsen J et al. (2000). "H19 RNA binds four molecules of insulin-like growth factor II mRNA-binding protein". J. Biol. Chem. 275 (38): 29562–9. doi:10.1074/jbc.M001156200. PMID 10875929.
Nielsen FC, Nielsen J, Kristensen MA et al. (2003). "Cytoplasmic trafficking of IGF-II mRNA-binding protein by conserved KH domains". J. Cell. Sci. 115 (Pt 10): 2087–97. PMID 11973350.
Lemm I, Ross J (2002). "Regulation of c-myc mRNA Decay by Translational Pausing in a Coding Region Instability Determinant". Mol. Cell. Biol. 22 (12): 3959–69. doi:10.1128/MCB.22.12.3959-3969.2002. PMC 133878. PMID 12024010. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=133878.
Ioannidis P, Mahaira L, Papadopoulou A et al. (2003). "8q24 Copy number gains and expression of the c-myc mRNA stabilizing protein CRD-BP in primary breast carcinomas". Int. J. Cancer 104 (1): 54–9. doi:10.1002/ijc.10794. PMID 12532419.
Nielsen J, Adolph SK, Rajpert-De Meyts E et al. (2003). "Nuclear transit of human zipcode-binding protein IMP1". Biochem. J. 376 (Pt 2): 383–91. doi:10.1042/BJ20030943. PMC 1223771. PMID 12921532. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1223771.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gu L, Shigemasa K, Ohama K (2004). "Increased expression of IGF II mRNA-binding protein 1 mRNA is associated with an advanced clinical stage and poor prognosis in patients with ovarian cancer". Int. J. Oncol. 24 (3): 671–8. PMID 14767552.
Hansen TV, Hammer NA, Nielsen J et al. (2004). "Dwarfism and Impaired Gut Development in Insulin-Like Growth Factor II mRNA-Binding Protein 1-Deficient Mice". Mol. Cell. Biol. 24 (10): 4448–64. doi:10.1128/MCB.24.10.4448-4464.2004. PMC 400488. PMID 15121863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=400488.
Ioannidis P, Kottaridi C, Dimitriadis E et al. (2004). "Expression of the RNA-binding protein CRD-BP in brain and non-small cell lung tumors". Cancer Lett. 209 (2): 245–50. doi:10.1016/j.canlet.2003.12.015. PMID 15159028.
Rackham O, Brown CM (2005). "Visualization of RNA–protein interactions in living cells: FMRP and IMP1 interact on mRNAs". EMBO J. 23 (16): 3346–55. doi:10.1038/sj.emboj.7600341. PMC 514514. PMID 15282548. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514514.
Nielsen J, Kristensen MA, Willemoës M et al. (2004). "Sequential dimerization of human zipcode-binding protein IMP1 on RNA: a cooperative mechanism providing RNP stability". Nucleic Acids Res. 32 (14): 4368–76. doi:10.1093/nar/gkh754. PMC 514376. PMID 15314207. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514376.
Suzuki Y, Yamashita R, Shirota M et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=515316.
Liao B, Patel M, Hu Y et al. (2005). "Targeted knockdown of the RNA-binding protein CRD-BP promotes cell proliferation via an insulin-like growth factor II-dependent pathway in human K562 leukemia cells". J. Biol. Chem. 279 (47): 48716–24. doi:10.1074/jbc.M405853200. PMID 15355996.

IGF2BP1

References

Further reading