IFIT2

Interferon-induced protein with tetratricopeptide repeats 2

Identifiers

IFIT2; G10P2; GARG-39; IFI-54; IFI-54K; IFI54; IFIT-2; ISG-54 K; ISG-54K; ISG54; cig42

External IDs

OMIM: 147040 MGI: 99449 HomoloGene: 1187 GeneCards: IFIT2 Gene

Gene Ontology
Molecular function	• molecular_function • protein binding
Cellular component	• cellular_component
Biological process	• biological_process • response to virus • cytokine-mediated signaling pathway • negative regulation of protein binding • cellular response to interferon-alpha • type I interferon-mediated signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 10:
91.06 – 91.07 Mb

Chr 19:
34.63 – 34.65 Mb

PubMed search

[1]

[2]

Interferon-induced protein with tetratricopeptide repeats 2 is a protein that in humans is encoded by the IFIT2 gene.^[1]^[2]^[3]

References

^ Wathelet MG, Szpirer J, Nols CB, Clauss IM, De Wit L, Islam MQ, Levan G, Horisberger MA et al. (Nov 1988). "Cloning and chromosomal location of human genes inducible by type I interferon". Somat Cell Mol Genet 14 (5): 415–26. doi:10.1007/BF01534709. PMID 3175763.
^ Wathelet MG, Clauss IM, Content J, Huez GA (Jun 1988). "The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family". FEBS Lett 231 (1): 164–71. doi:10.1016/0014-5793(88)80724-5. PMID 3360121.
^ "Entrez Gene: IFIT2 interferon-induced protein with tetratricopeptide repeats 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3433.

Lafage M, Clauss I, Couez D et al. (1992). "The interferon- and virus-inducible IFI-56K and IFI-54K genes are located on human chromosome 10 at bands q23-q24". Genomics 13 (2): 458–60. doi:10.1016/0888-7543(92)90272-T. PMID 1377167.
Wathelet MG, Clauss IM, Content J, Huez GA (1988). "Regulation of two interferon-inducible human genes by interferon, poly(rI).poly(rC) and viruses". Eur. J. Biochem. 174 (2): 323–9. doi:10.1111/j.1432-1033.1988.tb14101.x. PMID 2454816.
Ulker N, Zhang X, Samuel CE (1988). "Mechanism of interferon action. I. Characterization of a 54-kDa protein induced by gamma interferon with properties similar to a cytoskeletal component". J. Biol. Chem. 262 (35): 16798–803. PMID 3119591.
Levy D, Larner A, Chaudhuri A et al. (1987). "Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory region". Proc. Natl. Acad. Sci. U.S.A. 83 (23): 8929–33. doi:10.1073/pnas.83.23.8929. PMC 387047. PMID 3466167. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=387047.
Hillier LD, Lennon G, Becker M et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
Zhu H, Cong JP, Shenk T (1998). "Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: Induction of interferon-responsive RNAs". Proc. Natl. Acad. Sci. U.S.A. 94 (25): 13985–90. doi:10.1073/pnas.94.25.13985. PMC 28419. PMID 9391139. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=28419.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Gavrilov BG, Monastyrskaia GS, Velikodvorskaia TV et al. (2003). "[Late activation of interferon-induced genes IFI-54k and IFI-56k in human RH cells infected with tick-borne encephalitis virus]". Bioorg. Khim. 29 (2): 175–80. PMID 12708317.
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.
Terenzi F, Hui DJ, Merrick WC, Sen GC (2006). "Distinct induction patterns and functions of two closely related interferon-inducible human genes, ISG54 and ISG56". J. Biol. Chem. 281 (45): 34064–71. doi:10.1074/jbc.M605771200. PMID 16973618.
Saha S, Sugumar P, Bhandari P, Rangarajan PN (2006). "Identification of Japanese encephalitis virus-inducible genes in mouse brain and characterization of GARG39/IFIT2 as a microtubule-associated protein". J. Gen. Virol. 87 (Pt 11): 3285–9. doi:10.1099/vir.0.82107-0. PMID 17030862.
Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

IFIT2

References

Further reading