ICAM2
Intercellular adhesion molecule 2 (ICAM2), also known as CD102 (Cluster of Differentiation 102), is a human gene.
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.[1]
Interactions
ICAM2 has been shown to interact with EZR.[2]
See also
References
Further reading
- Simmons DL (1995). "The role of ICAM expression in immunity and disease.". Cancer Surv. 24: 141–55. PMID 7553659.
- Hayflick JS, Kilgannon P, Gallatin WM (1998). "The intercellular adhesion molecule (ICAM) family of proteins. New members and novel functions.". Immunol. Res. 17 (3): 313–27. doi:10.1007/BF02786454. PMID 9638475.
- Lalor PF, Shields P, Grant A, Adams DH (2002). "Recruitment of lymphocytes to the human liver.". Immunol. Cell Biol. 80 (1): 52–64. doi:10.1046/j.1440-1711.2002.01062.x. PMID 11869363.
- Yonekawa K, Harlan JM (2005). "Targeting leukocyte integrins in human diseases.". J. Leukoc. Biol. 77 (2): 129–40. doi:10.1189/jlb.0804460. PMID 15548573.
- de Fougerolles AR, Stacker SA, Schwarting R, Springer TA (1991). "Characterization of ICAM-2 and evidence for a third counter-receptor for LFA-1.". J. Exp. Med. 174 (1): 253–67. doi:10.1084/jem.174.1.253. PMC 2118873. PMID 1676048. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2118873.
- Sansom D, Borrow J, Solomon E, Trowsdale J (1992). "The human ICAM2 gene maps to 17q23-25.". Genomics 11 (2): 462–4. doi:10.1016/0888-7543(91)90157-A. PMID 1769660.
- Staunton DE, Dustin ML, Springer TA (1989). "Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1.". Nature 339 (6219): 61–4. doi:10.1038/339061a0. PMID 2497351.
- Bujía J, Holly A, Kim C, et al. (1994). "Expression of human intercellular adhesion molecules in middle ear cholesteatoma.". Am J Otolaryngol 15 (4): 271–5. doi:10.1016/0196-0709(94)90094-9. PMID 7526720.
- de Fougerolles AR, Qin X, Springer TA (1994). "Characterization of the function of intercellular adhesion molecule (ICAM)-3 and comparison with ICAM-1 and ICAM-2 in immune responses.". J. Exp. Med. 179 (2): 619–29. doi:10.1084/jem.179.2.619. PMC 2191386. PMID 7905020. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2191386.
- Butini L, De Fougerolles AR, Vaccarezza M, et al. (1994). "Intercellular adhesion molecules (ICAM)-1 ICAM-2 and ICAM-3 function as counter-receptors for lymphocyte function-associated molecule 1 in human immunodeficiency virus-mediated syncytia formation.". Eur. J. Immunol. 24 (9): 2191–5. doi:10.1002/eji.1830240939. PMID 7916296.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Hirao M, Sato N, Kondo T, et al. (1996). "Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway.". J. Cell Biol. 135 (1): 37–51. doi:10.1083/jcb.135.1.37. PMC 2121020. PMID 8858161. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2121020.
- Bernstein CN, Sargent M, Gallatin WM, Wilkins J (1996). "Beta 2-integrin/intercellular adhesion molecule (ICAM) expression in the normal human intestine.". Clin. Exp. Immunol. 106 (1): 160–9. PMID 8870715.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Casasnovas JM, Springer TA, Liu JH, et al. (1997). "Crystal structure of ICAM-2 reveals a distinctive integrin recognition surface.". Nature 387 (6630): 312–5. doi:10.1038/387312a0. PMID 9153399.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Sainio M, Zhao F, Heiska L, et al. (1997). "Neurofibromatosis 2 tumor suppressor protein colocalizes with ezrin and CD44 and associates with actin-containing cytoskeleton.". J. Cell. Sci.. 110 ( Pt 18): 2249–60. PMID 9378774.
- Yonemura S, Hirao M, Doi Y, et al. (1998). "Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2.". J. Cell Biol. 140 (4): 885–95. doi:10.1083/jcb.140.4.885. PMC 2141743. PMID 9472040. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2141743.
- Bernstein CN, Sargent M, Gallatin WM (1998). "Beta2 integrin/ICAM expression in Crohn's disease.". Clin. Immunol. Immunopathol. 86 (2): 147–60. doi:10.1006/clin.1997.4462. PMID 9473377.
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1zxq: THE CRYSTAL STRUCTURE OF ICAM-2
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External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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CD1 ( a-c, 1A, 1D, 1E) · CD2 · CD3 ( γ, δ, ε) · CD4 · CD5 · CD6 · CD7 · CD8 ( a) · CD9 · CD10 · CD11 ( a, b, c) · CD13 · CD14 · CD15 · CD16 ( A, B) · CD18 · CD19 · CD20 · CD21 · CD22 · CD23 · CD24 · CD25 · CD26 · CD27 · CD28 · CD29 · CD30 · CD31 · CD32 ( A, B) · CD33 · CD34 · CD35 · CD36 · CD37 · CD38 · CD39 · CD40 · CD41 · CD42 ( a, b, c, d) · CD43 · CD44 · CD45 · CD46 · CD47 · CD48 · CD49 ( a, b, c, d, e, f) · CD50
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| 51-100 |
CD51 · CD52 · CD53 · CD54 · CD55 · CD56 · CD57 · CD58 · CD59 · CD61 · CD62 ( E, L, P) · CD63 · CD64 ( A, B, C) · CD66 ( a, b, c, d, e, f) · CD68 · CD69 · CD70 · CD71 · CD72 · CD73 · CD74 · CD78 · CD79 ( a, b) · CD80 · CD81 · CD82 · CD83 · CD84 · CD85 ( a, d, e, h, j, k) · CD86 · CD87 · CD88 · CD89 · CD90 · CD91- CD92 · CD93 · CD94 · CD95 · CD96 · CD97 · CD98 · CD99 · CD100
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| 101-150 |
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| 151-200 |
CD151 · CD152 · CD153 · CD154 · CD155 · CD156 ( a, b, c) · CD157 · CD158 ( a, d, e, i, k) · CD159 ( a, c) · CD160 · CD161 · CD162 · CD163 · CD164 · CD166 · CD167 ( a, b) · CD168 · CD169 · CD170 · CD171 · CD172 ( a, b, g) · CD174 · CD177 · CD178 · CD179 ( a, b) · CD181 · CD182 · CD183 · CD184 · CD185 · CD186 · CD191 · CD192 · CD193 · CD194 · CD195 · CD196 · CD197 · CDw198 · CDw199 · CD200
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| 201-250 |
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| 251-300 |
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| 301-350 |
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