Hydrastine

Hydrastine

Systematic (IUPAC) name
6,7-dimethoxy-3-(6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-2-benzofuran-1(3H)-one
Clinical data
Pregnancy cat.	?
Legal status	?
Pharmacokinetic data
Metabolism	Hepatic
Excretion	Renal
Identifiers
CAS number	118-08-1^Y
ATC code	None
PubChem	CID 197835
ChemSpider	171234^Y
UNII	8890V3217X^Y
Chemical data
Formula	C₂₁H₂₁N O₆
Mol. mass	383.395 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C21H21NO6/c1-22-7-6-11-8-15-16(27-10-26-15)9-13(11)18(22)19-12-4-5-14(24-2)20(25-3)17(12)21(23)28-19/h4-5,8-9,18-19H,6-7,10H2,1-3H3/t18-,19+/m1/s1^Y Key:JZUTXVTYJDCMDU-MOPGFXCFSA-N^Y
Y(what is this?) (verify)

Hydrastine is a natural alkaloid which was discovered in 1851 by Alfred P. Durand.^[1] Hydrolysis of hydrastine yields hydrastinine, which was patented by Bayer as a haemostatic drug^[2] during the 1910s.

It is naturally present in Hydrastis canadensis (thus the name) and other plants of the ranunculaceae family.

References

^ American Journal of Pharmacy: 112, 1851 .
^ Römpp CD, Georg Thieme Verlag, 2006 .