Homotetramer

A homotetramer is a protein complex made up of four identical subunits which are associated but not covalently bound.[1] A heterotetramer is a 4-subunit complex where one or more subunits differ.[2]

Examples of homotetramers include: enzymes like beta-glucuronidase (pictured); export factors such as SecB from Escherichia coli[3] and magnesium ion transporters such as CorA.[4]

See also

References

  1. ^ "GO term: protein homotetramerization". YeastGenome. http://www.yeastgenome.org/cgi-bin/GO/goTerm.pl?goid=51289. Retrieved 14 May 2011. 
  2. ^ "GO term: protein heterotetramerization". YeastGenome. http://www.yeastgenome.org/cgi-bin/GO/goTerm.pl?goid=51290. Retrieved 14 May 2011. 
  3. ^ Watanabe, M; Blobel, G (1989 Apr). "Cytosolic factor purified from Escherichia coli is necessary and sufficient for the export of a preprotein and is a homotetramer of SecB.". Proceedings of the National Academy of Sciences of the United States of America 86 (8): 2728–32. doi:10.1073/pnas.86.8.2728. PMC 286991. PMID 2649892. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=286991. Retrieved 14 May 2011. 
  4. ^ Warren, M. A.; Kucharski, L. M., Veenstra, A., Shi, L., Grulich, P. F., Maguire, M. E. (1 July 2004). "The CorA Mg2+ Transporter Is a Homotetramer". Journal of Bacteriology 186 (14): 4605–4612. doi:10.1128/JB.186.14.4605-4612.2004. PMC 438605. PMID 15231793. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=438605. Retrieved 14 May 2011.