Homotaurine[1] | |
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3-Aminopropane-1-sulfonic acid |
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Other names
Tramiprosat; Alzhemed; 3aps |
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Identifiers | |
CAS number | 3687-18-1 |
PubChem | 1646 |
ChemSpider | 1584 |
KEGG | D06202 |
ChEMBL | CHEMBL149082 |
Jmol-3D images | Image 1 |
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Properties | |
Molecular formula | C3H9NO3S |
Molar mass | 139.17 g mol−1 |
Melting point |
293 °C (decomposition) |
Hazards | |
R-phrases | R36/37/38 |
S-phrases | S26 S36 |
(verify) (what is: / ?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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Infobox references |
Homotaurine (also spelled homotaurin) is a synthetic organic compound. It is analogous to taurine, but with an extra carbon in its chain. Because of its similarity in structure to the neurotransmitter gamma-aminobutyric acid (GABA), it has GABAergic effects and may be useful as an anticonvulsant.[2]
Homotaurine has also been investigated as a potential treatment for Alzheimer's disease. It binds to soluble amyloid beta and inhibits the formation of neurotoxic aggregates that lead to amyloid plaque deposition in the brain.[3] However, clinical trials failed to show value[4] [5]
Homotaurine is a zwitterion at neutral pH.