Hemoglobin variants

Hemoglobin variants are mutant forms of hemoglobin in a population (usually of humans), caused by variations in genetics. Some well-known hemoglobin variants such as sickle-cell anemia are responsible for diseases, and are considered hemoglobinopathies. Other variants cause no detectable pathology, and are thus considered non-pathological variants.

List of known hemoglobin variants

Hb Kansas (β102 Asn>Thr)^[1]
Hb S
Hb C
Hb E
Hb D-Punjab
Hb O-Arab
Hb G-Philadelphia
Hb Hasharon
Hb Korle-Bu
Hb Lepore
Hb M

References

^ Joseph Bonavetura and Austin Riggs, March 1968, "Hemoglobin Kansas, A Human Hemoglobin with a Neutral Amino Acid Substitution and an Abnormal Oxygen Equilibrium", The Journal of Biological Chemistry, Vol. 243, No. 5, Issue of March 10, pages 980-991.

External links

Proteins: hemeproteins

Globins

Hemoglobin

Subunits	Alpha locus on 16: α (HBA1, HBA2) · ζ (HBZ) · θ (HBQ1) · μ (HBM) Beta locus on 11: β (HBB) · δ (HBD) · γ (HBG1, HBG2) · ε (HBE1)

Tetramers	stages of development: HbA (α₂β₂) · HbA2 (α₂δ₂) · HbF/Fetal (α₂γ₂) · HbE Gower 2 (α₂ε₂) · HbE Gower 1 (ζ₂ε₂) pathology: HbH (β₄) · Barts (γ₄) · HbS (α₂β^S₂) · HbC (α₂β^C₂) · HbE (α₂β^E₂)

Compounds	Carboxyhemoglobin · Carbaminohemoglobin · Oxyhemoglobin/Deoxyhemoglobin · Sulfhemoglobin

Other human	Glycosylated hemoglobin · Methemoglobin

Nonhuman	Chlorocruorin · Erythrocruorin

Other

human: Myoglobin (Metmyoglobin) · Neuroglobin · Cytoglobin

plant: Leghemoglobin

Other

Cytochrome (Cytochrome b, Cytochrome P450) · Hemocyanin · Methemalbumin

see also disorders of globin and globulin proteins

M: MYL

cell/phys (coag, heme, immu, gran), csfs

rbmg/mogr/tumr/hist, sysi/epon, btst

drug (B1/2/3+5+6), btst, trns