Hemangiopericytoma
A hemangeopericytoma (HPC) is a type of soft tissue sarcoma that originates in the pericytes in the walls of capillaries. When inside the nervous system, although not strictly a meningioma tumor, it is a meningeal tumor with an especially aggressive behavior.
It was characterized in 1942.[1][2]
Description
Hemangiopericytoma located in the cerebral cavity is an aggressive tumor of the Mesenchyme with oval nuclei with scant cytoplasm. "There is dense intercellular reticulin staining. Tumor cells can be fibroblastic, myxoid, or pericytic. These tumors, in contrast to meningiomas, do not stain with epithelial membrane antigen. They have a grade 2 or 3 biological behavior, and need to be distinguished from benign meningiomas because of their high rate of recurrence (68.2%) and metastases (Maier et al 1992 [3]; Kleihues et al 1993 [4])." [5]
Treatment
Depending of the grade of the sarcoma, it is treated with surgery,[6] chemotherapy and/or radiotherapy.
See also
References
- ^ Brar R, Kulkarni S, Sheikh S, Jindal S, Brar P (June 2008). "Hemangieopericytoma associated with multiple keratocystic odontogenic tumors in an adolescent patient: a case report" (– Scholar search). J Oral Sci 50 (2): 233–7. doi:10.2334/josnusd.50.233. PMID 18587218. http://joi.jlc.jst.go.jp/JST.JSTAGE/josnusd/50.233?from=PubMed.
- ^ Stout AP, Murray MR(1942) Hemangiopericytoma: a vascular tumor featuring Zimmermann's pericytes. Ann Surg 116, 26-33
- ^ Maier H, Ofner D, Hittmair A, Kitz K, Budka H. (1992). "Classic, atypical, and anaplastic meningioma: three histopathological subtypes of clinical relevance.". Neurosurg (77): 616–23.
- ^ Kleihues P, Burger PC, Scheithauer BW. (1993). "Histological typing of tumours of the central nervous system. 2nd ed.". World Health Organization. Berlin : Springer-Verlag (30).
- ^ Sherman Sojka W MD, Raizer J MD, Dropcho E.J.MD. "Meningiomas". Medmerits: 2. http://www.medmerits.com/index.php/article/meningiomas/P1.
- ^ Ozaki N, Mukohara N, Yoshida M, Shida T (April 2006). "Successful resection of giant hemangeopericytoma originating from the left atrium". Interact Cardiovasc Thorac Surg 5 (2): 79–80. doi:10.1510/icvts.2005.124107. PMID 17670519. http://icvts.ctsnetjournals.org/cgi/pmidlookup?view=long&pmid=17670519.
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