HSPB8

Heat shock 22kDa protein 8
Identifiers
Symbols HSPB8; CMT2L; DHMN2; E2IG1; H11; HMN2; HMN2A; HSP22
External IDs OMIM608014 MGI2135756 HomoloGene8654 GeneCards: HSPB8 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 26353 80888
Ensembl ENSG00000152137 ENSMUSG00000041548
UniProt Q9UJY1 Q9JK92
RefSeq (mRNA) NM_014365.2 NM_030704.2
RefSeq (protein) NP_055180.1 NP_109629.1
Location (UCSC) Chr 12:
119.62 – 119.66 Mb
Chr 5:
116.86 – 116.87 Mb
PubMed search [1] [2]

Heat shock protein beta-8 is a protein that in humans is encoded by the HSPB8 gene.[1][2][3]

Contents

Interactions

HSPB8 has been shown to interact with Hsp27[4][5] and HSPB2.[4][6]

References

  1. ^ Smith CC, Yu YX, Kulka M, Aurelian L (Sep 2000). "A novel human gene similar to the protein kinase (PK) coding domain of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) codes for a serine-threonine PK and is expressed in melanoma cells". J Biol Chem 275 (33): 25690–9. doi:10.1074/jbc.M002140200. PMID 10833516. 
  2. ^ Charpentier AH, Bednarek AK, Daniel RL, Hawkins KA, Laflin KJ, Gaddis S, MacLeod MC, Aldaz CM (Nov 2000). "Effects of estrogen on global gene expression: identification of novel targets of estrogen action". Cancer Res 60 (21): 5977–83. PMID 11085516. 
  3. ^ "Entrez Gene: HSPB8 Heat shock 22kDa protein 8". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26353. 
  4. ^ a b Sun, Xiankui; Fontaine Jean-Marc, Rest Joshua S, Shelden Eric A, Welsh Michael J, Benndorf Rainer (Jan. 2004). "Interaction of human HSP22 (HSPB8) with other small heat shock proteins". J. Biol. Chem. (United States) 279 (4): 2394–402. doi:10.1074/jbc.M311324200. ISSN 0021-9258. PMID 14594798. 
  5. ^ Irobi, Joy; Van Impe Katrien, Seeman Pavel, Jordanova Albena, Dierick Ines, Verpoorten Nathalie, Michalik Andrej, De Vriendt Els, Jacobs An, Van Gerwen Veerle, Vennekens Krist'l, Mazanec Radim, Tournev Ivailo, Hilton-Jones David, Talbot Kevin, Kremensky Ivo, Van Den Bosch Ludo, Robberecht Wim, Van Vandekerckhove Joël, Van Broeckhoven Christine, Gettemans Jan, De Jonghe Peter, Timmerman Vincent (Jun. 2004). "Hot-spot residue in small heat-shock protein 22 causes distal motor neuropathy". Nat. Genet. (United States) 36 (6): 597–601. doi:10.1038/ng1328. ISSN 1061-4036. PMID 15122253. 
  6. ^ Benndorf, R; Sun X, Gilmont R R, Biederman K J, Molloy M P, Goodmurphy C W, Cheng H, Andrews P C, Welsh M J (Jul. 2001). "HSP22, a new member of the small heat shock protein superfamily, interacts with mimic of phosphorylated HSP27 ((3D)HSP27)". J. Biol. Chem. (United States) 276 (29): 26753–61. doi:10.1074/jbc.M103001200. ISSN 0021-9258. PMID 11342557. 

Further reading

External links