HSPB2

Heat shock 27kDa protein 2

Identifiers

HSPB2; HSP27; Hs.78846; LOH11CR1K; MGC133245; MKBP

External IDs

OMIM: 602179 MGI: 1916503 HomoloGene: 68189 GeneCards: HSPB2 Gene

Gene Ontology
Molecular function	• protein binding • enzyme activator activity
Cellular component	• nucleus • cytoplasm • cytosol
Biological process	• response to unfolded protein • response to heat • positive regulation of catalytic activity
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
111.29 – 111.29 Mb

Chr 9:
50.56 – 50.56 Mb

PubMed search

[1]

[2]

Heat shock protein beta-2 is a protein that in humans is encoded by the HSPB2 gene.^[1]^[2]^[3]

Interactions

HSPB2 has been shown to interact with TRAF6,^[4] HSPB8,^[5]^[6] Myotonic dystrophy protein kinase^[2]^[7] and CRYAB.^[7]

References

^ Iwaki A, Nagano T, Nakagawa M, Iwaki T, Fukumaki Y (Feb 1998). "Identification and characterization of the gene encoding a new member of the alpha-crystallin/small hsp family, closely linked to the alphaB-crystallin gene in a head-to-head manner". Genomics 45 (2): 386–94. doi:10.1006/geno.1997.4956. PMID 9344664.
^ ^a ^b Suzuki A, Sugiyama Y, Hayashi Y, Nyu-i N, Yoshida M, Nonaka I, Ishiura S, Arahata K, Ohno S (Apr 1998). "MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase". J Cell Biol 140 (5): 1113–24. doi:10.1083/jcb.140.5.1113. PMC 2132705. PMID 9490724. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2132705.
^ "Entrez Gene: HSPB2 heat shock 27kDa protein 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3316.
^ Wu, Yifan; Liu Junhong, Zhang Zhengping, Huang Huang, Shen Jiayin, Zhang Shuangquan, Jiang Yong, Luo Lan, Yin Zhimin (Jan. 2009). "HSP27 regulates IL-1 stimulated IKK activation through interacting with TRAF6 and affecting its ubiquitination". Cell. Signal. (England) 21 (1): 143–50. doi:10.1016/j.cellsig.2008.10.001. PMID 18950704.
^ Sun, Xiankui; Fontaine Jean-Marc, Rest Joshua S, Shelden Eric A, Welsh Michael J, Benndorf Rainer (Jan. 2004). "Interaction of human HSP22 (HSPB8) with other small heat shock proteins". J. Biol. Chem. (United States) 279 (4): 2394–402. doi:10.1074/jbc.M311324200. ISSN 0021-9258. PMID 14594798.
^ Benndorf, R; Sun X, Gilmont R R, Biederman K J, Molloy M P, Goodmurphy C W, Cheng H, Andrews P C, Welsh M J (Jul. 2001). "HSP22, a new member of the small heat shock protein superfamily, interacts with mimic of phosphorylated HSP27 ((3D)HSP27)". J. Biol. Chem. (United States) 276 (29): 26753–61. doi:10.1074/jbc.M103001200. ISSN 0021-9258. PMID 11342557.
^ ^a ^b Sugiyama, Y; Suzuki A, Kishikawa M, Akutsu R, Hirose T, Waye M M, Tsui S K, Yoshida S, Ohno S (Jan. 2000). "Muscle develops a specific form of small heat shock protein complex composed of MKBP/HSPB2 and HSPB3 during myogenic differentiation". J. Biol. Chem. (UNITED STATES) 275 (2): 1095–104. doi:10.1074/jbc.275.2.1095. ISSN 0021-9258. PMID 10625651.

Concannon CG, Gorman AM, Samali A (2003). "On the role of Hsp27 in regulating apoptosis.". Apoptosis 8 (1): 61–70. doi:10.1023/A:1021601103096. PMID 12510153.
Elisei R, Weightman D, Kendall-Taylor P, et al. (1993). "Muscle autoantigens in thyroid associated ophthalmopathy: the limits of molecular genetics.". J. Endocrinol. Invest. 16 (7): 533–40. PMID 8227983.
Deak M, Clifton AD, Lucocq LM, Alessi DR (1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB.". EMBO J. 17 (15): 4426–41. doi:10.1093/emboj/17.15.4426. PMC 1170775. PMID 9687510. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170775.
Sugiyama Y, Suzuki A, Kishikawa M, et al. (2000). "Muscle develops a specific form of small heat shock protein complex composed of MKBP/HSPB2 and HSPB3 during myogenic differentiation.". J. Biol. Chem. 275 (2): 1095–104. doi:10.1074/jbc.275.2.1095. PMID 10625651.
Baysal BE, Willett-Brozick JE, Taschner PE, et al. (2001). "A high-resolution integrated map spanning the SDHD gene at 11q23: a 1.1-Mb BAC contig, a partial transcript map and 15 new repeat polymorphisms in a tumour-suppressor region.". Eur. J. Hum. Genet. 9 (2): 121–9. doi:10.1038/sj.ejhg.5200585. PMID 11313745.
Nakagawa M, Tsujimoto N, Nakagawa H, et al. (2001). "Association of HSPB2, a member of the small heat shock protein family, with mitochondria.". Exp. Cell Res. 271 (1): 161–8. doi:10.1006/excr.2001.5362. PMID 11697892.
Ito H, Kamei K, Iwamoto I, et al. (2002). "Inhibition of proteasomes induces accumulation, phosphorylation, and recruitment of HSP27 and alphaB-crystallin to aggresomes.". J. Biochem. 131 (4): 593–603. PMID 11926998.
Boxman IL, Kempenaar J, de Haas E, Ponec M (2003). "Induction of HSP27 nuclear immunoreactivity during stress is modulated by vitamin C.". Exp. Dermatol. 11 (6): 509–17. doi:10.1034/j.1600-0625.2002.110603.x. PMID 12473058.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Patel VM, Heinel LA, Provencio JJ, et al. (2003). "Validation of image analysis for enzyme histochemical and immunocytochemical staining.". Biotechnic & histochemistry : official publication of the Biological Stain Commission 77 (4): 213–21. PMID 12503731.
Mao H, Li F, Ruchalski K, et al. (2003). "hsp72 inhibits focal adhesion kinase degradation in ATP-depleted renal epithelial cells.". J. Biol. Chem. 278 (20): 18214–20. doi:10.1074/jbc.M300126200. PMID 12611892.
Yonekura N, Yokota S, Yonekura K, et al. (2003). "Interferon-gamma downregulates Hsp27 expression and suppresses the negative regulation of cell death in oral squamous cell carcinoma lines.". Cell Death Differ. 10 (3): 313–22. doi:10.1038/sj.cdd.4401169. PMID 12700631.
Kantham L, Kerr-Bayles L, Godde N, et al. (2003). "Beacon interacts with cdc2/cdc28-like kinases.". Biochem. Biophys. Res. Commun. 304 (1): 125–9. doi:10.1016/S0006-291X(03)00549-7. PMID 12705895.
Yaglom J, O'Callaghan-Sunol C, Gabai V, Sherman MY (2003). "Inactivation of dual-specificity phosphatases is involved in the regulation of extracellular signal-regulated kinases by heat shock and hsp72.". Mol. Cell. Biol. 23 (11): 3813–24. doi:10.1128/MCB.23.11.3813-3824.2003. PMC 155207. PMID 12748284. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=155207.
Park KJ, Gaynor RB, Kwak YT (2003). "Heat shock protein 27 association with the I kappa B kinase complex regulates tumor necrosis factor alpha-induced NF-kappa B activation.". J. Biol. Chem. 278 (37): 35272–8. doi:10.1074/jbc.M305095200. PMID 12829720.
Wen FC, Li YH, Tsai HF, et al. (2003). "Down-regulation of heat shock protein 27 in neuronal cells and non-neuronal cells expressing mutant ataxin-3.". FEBS Lett. 546 (2-3): 307–14. doi:10.1016/S0014-5793(03)00605-7. PMID 12832059.
Parcellier A, Schmitt E, Gurbuxani S, et al. (2003). "HSP27 is a ubiquitin-binding protein involved in I-kappaBalpha proteasomal degradation.". Mol. Cell. Biol. 23 (16): 5790–802. doi:10.1128/MCB.23.16.5790-5802.2003. PMC 166315. PMID 12897149. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=166315.

HSPB2

Interactions

References

Further reading