HSD17B8

Hydroxysteroid (17-beta) dehydrogenase 8

PDB rendering based on 2pd6.

Available structures
PDB	2pd6

Identifiers

Symbols

HSD17B8; D6S2245E; FABG; FABGL; H2-KE6; HKE6; KE6; RING2; SDR30C1; dJ1033B10.9

External IDs

OMIM: 601417 MGI: 95911 HomoloGene: 56588 GeneCards: HSD17B8 Gene

Gene Ontology
Molecular function	• 3-hydroxyacyl-CoA dehydrogenase activity • estradiol 17-beta-dehydrogenase activity • protein binding • oxidoreductase activity • testosterone 17-beta-dehydrogenase (NAD+) activity
Cellular component	• membrane fraction • mitochondrion • mitochondrial envelope • mitochondrial matrix • plasma membrane
Biological process	• fatty acid biosynthetic process • estrogen biosynthetic process • androgen metabolic process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr c6_QBL:
33.24 – 33.25 Mb

Chr 17:
34.16 – 34.17 Mb

PubMed search

[1]

[2]

Estradiol 17-beta-dehydrogenase 8 is an enzyme that in humans is encoded by the HSD17B8 gene.^[1]^[2]^[3]

In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined.^[3]

References

^ Ando A, Kikuti YY, Shigenari A, Kawata H, Okamoto N, Shiina T, Chen L, Ikemura T, Abe K, Kimura M, Inoko H (Dec 1996). "cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region". Genomics 35 (3): 600–2. doi:10.1006/geno.1996.0405. PMID 8812499.
^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2896744.
^ ^a ^b "Entrez Gene: HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7923.

Kikuti YY, Tamiya G, Ando A, et al. (1997). "Physical mapping 220 kb centromeric of the human MHC and DNA sequence analysis of the 43-kb segment including the RING1, HKE6, and HKE4 genes". Genomics 42 (3): 422–35. doi:10.1006/geno.1997.4745. PMID 9205114.
Fomitcheva J, Baker ME, Anderson E, et al. (1998). "Characterization of Ke 6, a new 17beta-hydroxysteroid dehydrogenase, and its expression in gonadal tissues". J. Biol. Chem. 273 (35): 22664–71. doi:10.1074/jbc.273.35.22664. PMID 9712896.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948.
Aziz N, Anderson E, Lee GY, Woo DD (2001). "Arrested testis development in the cpk mouse may be the result of abnormal steroid metabolism". Mol. Cell. Endocrinol. 171 (1–2): 83–8. doi:10.1016/S0303-7207(00)00390-7. PMID 11165015.
Kutsenko AS, Gizatullin RZ, Al-Amin AN, et al. (2002). "NotI flanking sequences: a tool for gene discovery and verification of the human genome". Nucleic Acids Res. 30 (14): 3163–70. doi:10.1093/nar/gkf428. PMC 135748. PMID 12136098. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=135748.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528930.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1347501.
Song D, Liu G, Luu-The V, et al. (2006). "Expression of aromatase and 17beta-hydroxysteroid dehydrogenase types 1, 7 and 12 in breast cancer. An immunocytochemical study". J. Steroid Biochem. Mol. Biol. 101 (2–3): 136–44. doi:10.1016/j.jsbmb.2006.06.015. PMID 16930994.
Villar J, Celay J, Alonso MM, et al. (2007). "Transcriptional regulation of the human type 8 17beta-hydroxysteroid dehydrogenase gene by C/EBPbeta". J. Steroid Biochem. Mol. Biol. 105 (1–5): 131–9. doi:10.1016/j.jsbmb.2006.12.106. PMID 17583490.

PDB gallery

2pd6: Structure of human hydroxysteroid dehydrogenase type 8, HSD17B8

HSD17B8

References

Further reading