HSD17B2

Hydroxysteroid (17-beta) dehydrogenase 2

Identifiers

HSD17B2; EDH17B2; HSD17; SDR9C2

External IDs

OMIM: 109685 MGI: 1096386 HomoloGene: 99709 GeneCards: HSD17B2 Gene

Gene Ontology
Molecular function	• estradiol 17-beta-dehydrogenase activity • binding • oxidoreductase activity • 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity • testosterone 17-beta-dehydrogenase (NAD+) activity
Cellular component	• endoplasmic reticulum membrane • membrane • integral to membrane
Biological process	• steroid biosynthetic process • response to retinoic acid
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 16:
82.07 – 82.13 Mb

Chr 8:
120.23 – 120.28 Mb

PubMed search

[1]

[2]

Estradiol 17-beta-dehydrogenase 2 is an enzyme that in humans is encoded by the HSD17B2 gene.^[1]^[2]^[3]

References

^ Durocher F, Morissette J, Labrie Y, Labrie F, Simard J (Jun 1995). "Mapping of the HSD17B2 gene encoding type II 17 beta-hydroxysteroid dehydrogenase close to D16S422 on chromosome 16q24.1-q24.2". Genomics 25 (3): 724–6. doi:10.1016/0888-7543(95)80017-G. PMID 7759109.
^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact 178 (1-3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2896744.
^ "Entrez Gene: HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3294.

Labrie Y, Durocher F, Lachance Y, et al. (1995). "The human type II 17 beta-hydroxysteroid dehydrogenase gene encodes two alternatively spliced mRNA species.". DNA Cell Biol. 14 (10): 849–61. doi:10.1089/dna.1995.14.849. PMID 7546291.
Andersson S, Geissler WM, Patel S, Wu L (1995). "The molecular biology of androgenic 17 beta-hydroxysteroid dehydrogenases.". J. Steroid Biochem. Mol. Biol. 53 (1-6): 37–9. doi:10.1016/0960-0760(95)00039-3. PMID 7626483.
Carsol JL, Martin PM, de Launoit Y (1995). "Characterization of 17 beta-hydroxysteroid dehydrogenase activity and mRNA abundance in human meningioma tumors.". Neuroendocrinology 60 (4): 445–51. doi:10.1159/000126779. PMID 7824086.
Wu L, Einstein M, Geissler WM, et al. (1993). "Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity.". J. Biol. Chem. 268 (17): 12964–9. PMID 8099587.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Zhang Y, Word RA, Fesmire S, et al. (1996). "Human ovarian expression of 17 beta-hydroxysteroid dehydrogenase types 1, 2, and 3.". J. Clin. Endocrinol. Metab. 81 (10): 3594–8. doi:10.1210/jc.81.10.3594. PMID 8855807.
Moghrabi N, Head JR, Andersson S (1997). "Cell type-specific expression of 17 beta-hydroxysteroid dehydrogenase type 2 in human placenta and fetal liver.". J. Clin. Endocrinol. Metab. 82 (11): 3872–8. doi:10.1210/jc.82.11.3872. PMID 9360554.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Corbould AM, Judd SJ, Rodgers RJ (1998). "Expression of types 1, 2, and 3 17 beta-hydroxysteroid dehydrogenase in subcutaneous abdominal and intra-abdominal adipose tissue of women.". J. Clin. Endocrinol. Metab. 83 (1): 187–94. doi:10.1210/jc.83.1.187. PMID 9435439.
Dong Y, Qiu QQ, Debear J, et al. (1999). "17Beta-hydroxysteroid dehydrogenases in human bone cells.". J. Bone Miner. Res. 13 (10): 1539–46. doi:10.1359/jbmr.1998.13.10.1539. PMID 9783542.
Kitawaki J, Koshiba H, Ishihara H, et al. (2000). "Progesterone induction of 17beta-hydroxysteroid dehydrogenase type 2 during the secretory phase occurs in the endometrium of estrogen-dependent benign diseases but not in normal endometrium.". J. Clin. Endocrinol. Metab. 85 (9): 3292–6. doi:10.1210/jc.85.9.3292. PMID 10999824.
Sano T, Hirasawa G, Takeyama J, et al. (2001). "17 beta-Hydroxysteroid dehydrogenase type 2 expression and enzyme activity in the human gastrointestinal tract.". Clin. Sci. 101 (5): 485–91. doi:10.1042/CS20010052. PMID 11672453.
Lu ML, Huang YW, Lin SX (2002). "Purification, reconstitution, and steady-state kinetics of the trans-membrane 17 beta-hydroxysteroid dehydrogenase 2.". J. Biol. Chem. 277 (25): 22123–30. doi:10.1074/jbc.M111726200. PMID 11940569.
Provost PR, Blomquist CH, Drolet R, et al. (2002). "Androgen inactivation in human lung fibroblasts: variations in levels of 17 beta-hydroxysteroid dehydrogenase type 2 and 5 alpha-reductase activity compatible with androgen inactivation.". J. Clin. Endocrinol. Metab. 87 (8): 3883–92. doi:10.1210/jc.87.8.3883. PMID 12161528.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Oliveira IO, Lhullier C, Brum IS, Spritzer PM (2004). "Gene expression of type 2 17 beta hydroxysteroid dehydrogenase in scalp hairs of hirsute women.". Steroids 68 (7-8): 641–9. doi:10.1016/S0039-128X(03)00093-X. PMID 12957669.
Oduwole OO, Mäkinen JM, Isomaa VV, et al. (2004). "Sex steroid metabolism in human gastric mucosa: 17 beta-hydroxysteroid dehydrogenase type 2 in normal, inflamed and neoplastic gastric tissues.". Anticancer Res. 23 (5A): 3889–97. PMID 14666693.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Matsuzaki S, Canis M, Pouly JL, et al. (2006). "Analysis of aromatase and 17beta-hydroxysteroid dehydrogenase type 2 messenger ribonucleic acid expression in deep endometriosis and eutopic endometrium using laser capture microdissection.". Fertil. Steril. 85 (2): 308–13. doi:10.1016/j.fertnstert.2005.08.017. PMID 16595205.

HSD17B2

References

Further reading