HSD17B1

Hydroxysteroid (17-beta) dehydrogenase 1

PDB rendering based on 1a27.
Identifiers
Symbols HSD17B1; EDH17B2; EDHB17; HSD17; MGC138140; SDR28C1
External IDs OMIM: 109684 MGI: 105077 HomoloGene: 37303 GeneCards: HSD17B1 Gene
EC number 1.1.1.62
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 3292 15485
Ensembl ENSG00000108786 ENSMUSG00000019301
UniProt P14061 Q3UPP5
RefSeq (mRNA) NM_000413.2 NM_010475.1
RefSeq (protein) NP_000404.2 NP_034605.1
Location (UCSC) Chr 17:
40.7 – 40.71 Mb		 Chr 11:
100.94 – 100.94 Mb
PubMed search [1] [2]

Estradiol 17-beta-dehydrogenase 1 is an enzyme that in humans is encoded by the HSD17B1 gene.[1][2][3]

References

  1. ^ Luu-The V, Labrie C, Simard J, Lachance Y, Zhao HF, Couet J, Leblanc G, Labrie F (May 1990). "Structure of two in tandem human 17 beta-hydroxysteroid dehydrogenase genes". Mol Endocrinol 4 (2): 268–75. doi:10.1210/mend-4-2-268. PMID 2330005. 
  2. ^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2896744. 
  3. ^ "Entrez Gene: HSD17B1 Hydroxysteroid (17-beta) dehydrogenase 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3292. 

Further reading

  • Blomquist CH (1996). "Kinetic analysis of enzymic activities: prediction of multiple forms of 17 beta-hydroxysteroid dehydrogenase". J. Steroid Biochem. Mol. Biol. 55 (5–6): 515–24. doi:10.1016/0960-0760(95)00200-6. PMID 8547176. 
  • Lin SX, Shi R, Qiu W, et al. (2006). "Structural basis of the multispecificity demonstrated by 17beta-hydroxysteroid dehydrogenase types 1 and 5". Mol. Cell. Endocrinol. 248 (1–2): 38–46. doi:10.1016/j.mce.2005.11.035. PMID 16480815. 
  • Peltoketo H, Isomaa V, Vihko R (1992). "Genomic organization and DNA sequences of human 17 beta-hydroxysteroid dehydrogenase genes and flanking regions. Localization of multiple Alu sequences and putative cis-acting elements". Eur. J. Biochem. 209 (1): 459–66. doi:10.1111/j.1432-1033.1992.tb17310.x. PMID 1327779. 
  • Winqvist R, Peltoketo H, Isomaa V, et al. (1990). "The gene for 17 beta-hydroxysteroid dehydrogenase maps to human chromosome 17, bands q12-q21, and shows an RFLP with ScaI". Hum. Genet. 85 (5): 473–6. doi:10.1007/BF00194219. PMID 1977681. 
  • Luu-The V, Labrie C, Zhao HF, et al. (1990). "Purification, cloning, complementary DNA structure, and predicted amino acid sequence of human estradiol 17 beta-dehydrogenase". Ann. N. Y. Acad. Sci. 595: 40–52. doi:10.1111/j.1749-6632.1990.tb34281.x. PMID 2197970. 
  • Baker ME (1989). "Human placental 17 beta-hydroxysteroid dehydrogenase is homologous to NodG protein of Rhizobium meliloti". Mol. Endocrinol. 3 (5): 881–4. doi:10.1210/mend-3-5-881. PMID 2547159. 
  • Tremblay Y, Ringler GE, Morel Y, et al. (1990). "Regulation of the gene for estrogenic 17-ketosteroid reductase lying on chromosome 17cen----q25". J. Biol. Chem. 264 (34): 20458–62. PMID 2584224. 
  • Luu The V, Labrie C, Zhao HF, et al. (1989). "Characterization of cDNAs for human estradiol 17 beta-dehydrogenase and assignment of the gene to chromosome 17: evidence of two mRNA species with distinct 5'-termini in human placenta". Mol. Endocrinol. 3 (8): 1301–9. doi:10.1210/mend-3-8-1301. PMID 2779584. 
  • Peltoketo H, Isomaa V, Mäentausta O, Vihko R (1988). "Complete amino acid sequence of human placental 17 beta-hydroxysteroid dehydrogenase deduced from cDNA". FEBS Lett. 239 (1): 73–7. doi:10.1016/0014-5793(88)80548-9. PMID 2846351. 
  • Nicolas JC, Harris JI (1973). "Human placental 17 -oestradiol dehydrogenase. Sequence of a tryptic peptide containing an essential cysteine". FEBS Lett. 29 (2): 173–6. doi:10.1016/0014-5793(73)80554-X. PMID 4719204. 
  • Burns DJ, Engel LL, Bethune JL (1972). "Amino acid composition and subunit structure. Human placental 17 -estradiol dehydrogenase". Biochemistry 11 (14): 2699–703. doi:10.1021/bi00764a023. PMID 5045524. 
  • Murdock GL, Chin CC, Offord RE, et al. (1983). "Human placental estradiol 17 beta-dehydrogenase. Identification of a single histidine residue affinity-labeled by both 3-bromoacetoxyestrone and 12 beta-bromoacetoxy-4-estrene-3,17-dione". J. Biol. Chem. 258 (19): 11460–4. PMID 6578212. 
  • Andersson S, Geissler WM, Patel S, Wu L (1995). "The molecular biology of androgenic 17 beta-hydroxysteroid dehydrogenases". J. Steroid Biochem. Mol. Biol. 53 (1–6): 37–9. doi:10.1016/0960-0760(95)00039-3. PMID 7626483. 
  • Tremblay MR, Auger S, Poirier D (1995). "Synthesis of 16-(bromoalkyl)-estradiols having inhibitory effect on human placental estradiol 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD type 1)". Bioorg. Med. Chem. 3 (5): 505–23. doi:10.1016/0968-0896(95)00041-E. PMID 7648200. 
  • Ghosh D, Pletnev VZ, Zhu DW, et al. (1995). "Structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase at 2.20 A resolution". Structure 3 (5): 503–13. doi:10.1016/S0969-2126(01)00183-6. PMID 7663947. 
  • Sawetawan C, Milewich L, Word RA, et al. (1994). "Compartmentalization of type I 17 beta-hydroxysteroid oxidoreductase in the human ovary". Mol. Cell. Endocrinol. 99 (2): 161–8. doi:10.1016/0303-7207(94)90004-3. PMID 8206323. 
  • Normand T, Narod S, Labrie F, Simard J (1993). "Detection of polymorphisms in the estradiol 17 beta-hydroxysteroid dehydrogenase II gene at the EDH17B2 locus on 17q11-q21". Hum. Mol. Genet. 2 (4): 479–83. doi:10.1093/hmg/2.4.479. PMID 8389226. 
  • Zhao Z, Yazdani A, Shen Y, et al. (1996). "Molecular dissection of a cosmid from a gene-rich region in 17q21 and characterization of a candidate gene for alpha-N-acetylglucosaminidase with two cDNA isoforms". Mamm. Genome 7 (9): 686–90. doi:10.1007/s003359900206. PMID 8703123.