HOXA9

Homeobox A9

PDB rendering based on 1puf.
Identifiers
Symbols HOXA9; ABD-B; HOX1; HOX1.7; HOX1G; MGC1934
External IDs OMIM: 142956 MGI: 96180 HomoloGene: 7766 GeneCards: HOXA9 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 3205 15405
Ensembl ENSG00000078399 ENSMUSG00000038227
UniProt P31269 P09631
RefSeq (mRNA) NM_152739.3 NM_010456.2
RefSeq (protein) NP_689952.1 NP_034586.1
Location (UCSC) Chr 7:
27.2 – 27.22 Mb		 Chr 6:
52.17 – 52.18 Mb
PubMed search [1] [2]

Homeobox protein Hox-A9 is a protein that in humans is encoded by the HOXA9 gene.[1][2]

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis.[3]

Contents

See also

Interactions

HOXA9 has been shown to interact with PBX2,[4] TRIP6[5] and MEIS1.[6][4]

References

  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
  3. ^ "Entrez Gene: HOXA9 homeobox A9". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3205. 
  4. ^ a b Shen, W F; Rozenfeld S, Kwong A, Köm ves L G, Lawrence H J, Largman C (Apr. 1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Mol. Cell. Biol. (UNITED STATES) 19 (4): 3051–61. ISSN 0270-7306. PMC 84099. PMID 10082572. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84099. 
  5. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  6. ^ Shen, W F; Montgomery J C, Rozenfeld S, Moskow J J, Lawrence H J, Buchberg A M, Largman C (Nov. 1997). "AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins". Mol. Cell. Biol. (UNITED STATES) 17 (11): 6448–58. ISSN 0270-7306. PMC 232497. PMID 9343407. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=232497. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.