HMOX2

Heme oxygenase (decycling) 2

PDB rendering based on 2q32.

Available structures
PDB	2Q32, 2QPP, 2RGZ

Identifiers

Symbols

HMOX2; HO-2

External IDs

OMIM: 141251 MGI: 109373 HomoloGene: 1611 GeneCards: HMOX2 Gene

EC number

1.14.99.3

Gene Ontology
Molecular function	• heme oxygenase (decyclizing) activity • heme oxygenase (decyclizing) activity • protein binding • electron carrier activity • oxidoreductase activity • metal ion binding
Cellular component	• endoplasmic reticulum • endoplasmic reticulum membrane • microsome • plasma membrane
Biological process	• response to hypoxia • porphyrin metabolic process • heme oxidation • cellular iron ion homeostasis • response to oxidative stress • heme catabolic process • transmembrane transport
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 16:
4.52 – 4.56 Mb

Chr 16:
4.73 – 4.77 Mb

PubMed search

[1]

[2]

Heme oxygenase 2 is an enzyme that in humans is encoded by the HMOX2 gene.^[1]^[2]

Function

Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 (this enzyme) belong to the heme oxygenase family.^[2]

References

^ McCoubrey WK Jr, Ewing JF, Maines MD (Jun 1992). "Human heme oxygenase-2: characterization and expression of a full-length cDNA and evidence suggesting that the two HO-2 transcripts may differ by choice of polyadenylation signal". Arch Biochem Biophys 295 (1): 13–20. doi:10.1016/0003-9861(92)90481-B. PMID 1575508.
^ ^a ^b "Entrez Gene: HMOX2 heme oxygenase (decycling) 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3163.

Bianchetti CM, Yi L, Ragsdale SW, Phillips GN Jr. (2007). "Comparison of Apo- and Heme-bound Crystal Structures of a Truncated Human Heme Oxygenase-2". J Biol Chem. 282 (52): 37624–31. doi:10.1074/jbc.M707396200. PMC 2896506. PMID 17965015. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2896506.
Barañano DE, Snyder SH (2001). "Neural roles for heme oxygenase: Contrasts to nitric oxide synthase". Proc. Natl. Acad. Sci. U.S.A. 98 (20): 10996–1002. doi:10.1073/pnas.191351298. PMC 58673. PMID 11572959. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=58673.
Doré S (2002). "Decreased activity of the antioxidant heme oxygenase enzyme: implications in ischemia and in Alzheimer's disease". Free Radic. Biol. Med. 32 (12): 1276–82. doi:10.1016/S0891-5849(02)00805-5. PMID 12057765.
Kemp PJ (2005). "Hemeoxygenase-2 as an O2 sensor in K+ channel-dependent chemotransduction". Biochem. Biophys. Res. Commun. 338 (1): 648–52. doi:10.1016/j.bbrc.2005.08.110. PMID 16137652.
Ishikawa K, Takeuchi N, Takahashi S, et al. (1995). "Heme oxygenase-2. Properties of the heme complex of the purified tryptic fragment of recombinant human heme oxygenase-2". J. Biol. Chem. 270 (11): 6345–50. doi:10.1074/jbc.270.11.6345. PMID 7890772.
Kutty RK, Kutty G, Rodriguez IR, et al. (1994). "Chromosomal localization of the human heme oxygenase genes: heme oxygenase-1 (HMOX1) maps to chromosome 22q12 and heme oxygenase-2 (HMOX2) maps to chromosome 16p13.3". Genomics 20 (3): 513–6. doi:10.1006/geno.1994.1213. PMID 8034330.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Takahashi K, Hara E, Suzuki H, et al. (1996). "Expression of heme oxygenase isozyme mRNAs in the human brain and induction of heme oxygenase-1 by nitric oxide donors". J. Neurochem. 67 (2): 482–9. doi:10.1046/j.1471-4159.1996.67020482.x. PMID 8764571.
Saito-Ohara F, Ikeuchi T, Matsumoto M, Kurata S (1997). "Assignment of the mouse heme oxygenase genes: heme oxygenase-1 (Hmox1) to chromosome 10 band C1 and heme oxygenase-2 (Hmox2) to chromosome 16 band B1". Cytogenet. Cell Genet. 77 (3–4): 180–1. doi:10.1159/000134570. PMID 9284910.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Yoshiki N, Kubota T, Aso T (2000). "Expression and localization of heme oxygenase in human placental villi". Biochem. Biophys. Res. Commun. 276 (3): 1136–42. doi:10.1006/bbrc.2000.3551. PMID 11027601.
Hanselmann C, Mauch C, Werner S (2001). "Haem oxygenase-1: a novel player in cutaneous wound repair and psoriasis?". Biochem. J. 353 (Pt 3): 459–66. doi:10.1042/0264-6021:3530459. PMC 1221590. PMID 11171041. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1221590.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Appleton SD, Marks GS, Nakatsu K, et al. (2003). "Effects of hypoxia on heme oxygenase expression in human chorionic villi explants and immortalized trophoblast cells". Am. J. Physiol. Heart Circ. Physiol. 284 (3): H853–8. doi:10.1152/ajpheart.00655.2002 (inactive 2008-10-03). PMID 12578814.
Galey D, Becker K, Haughey N, et al. (2003). "Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes". J. Neurovirol. 9 (3): 358–71. doi:10.1080/713831545. PMID 12775419.
Zenclussen AC, Lim E, Knoeller S, et al. (2004). "Heme oxygenases in pregnancy II: HO-2 is downregulated in human pathologic pregnancies". Am. J. Reprod. Immunol. 50 (1): 66–76. doi:10.1034/j.1600-0897.2003.00047.x. PMID 14506930.
Boehning D, Moon C, Sharma S, et al. (2003). "Carbon monoxide neurotransmission activated by CK2 phosphorylation of heme oxygenase-2". Neuron 40 (1): 129–37. doi:10.1016/S0896-6273(03)00596-8. PMID 14527438.
Appleton SD, Lash GE, Marks GS, et al. (2004). "Effect of glucose and oxygen deprivation on heme oxygenase expression in human chorionic villi explants and immortalized trophoblast cells". Am. J. Physiol. Regul. Integr. Comp. Physiol. 285 (6): R1453–60. doi:10.1152/ajpregu.00234.2003 (inactive 2008-10-03). PMID 14615405.

PDB gallery

2q32: Crystal structure of human heme oxygenase-2 C127A (HO-2)

HMOX2

Function

References

Further reading