HMHA1

Histocompatibility (minor) HA-1

Identifiers

HMHA1; HA-1; HLA-HA1; KIAA0223

External IDs

OMIM: 601155 MGI: 1917969 HomoloGene: 69120 GeneCards: HMHA1 Gene

Gene Ontology
Molecular function	• GTPase activator activity • metal ion binding
Cellular component	• cytosol
Biological process	• small GTPase mediated signal transduction • positive regulation of GTPase activity • regulation of small GTPase mediated signal transduction
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 19:
1.07 – 1.09 Mb

Chr 10:
79.48 – 79.49 Mb

PubMed search

[1]

[2]

Minor histocompatibility protein HA-1 is a protein that in humans is encoded by the HMHA1 gene.^[1]^[2]^[3]

References

^ Wilke M, Pool J, den Haan JM, Goulmy E (Jan 1999). "Genomic identification of the minor histocompatibility antigen HA-1 locus by allele-specific PCR". Tissue Antigens 52 (4): 312–317. doi:10.1111/j.1399-0039.1998.tb03053.x. PMID 9820596.
^ Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (May 1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res 3 (5): 321–329. doi:10.1093/dnares/3.5.321. PMID 9039502.
^ "Entrez Gene: HMHA1 histocompatibility (minor) HA-1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23526.

van Lochem E, van der Keur M, Mommaas AM et al. (1997). "Functional expression of minor histocompatibility antigens on human peripheral blood dendritic cells and epidermal Langerhans cells". Transpl. Immunol. 4 (2): 151–157. doi:10.1016/S0966-3274(96)80009-8. PMID 8843592.
Aróstegui JI, Gallardo D, Rodríguez-Luaces M et al. (2001). "Genomic typing of minor histocompatibility antigen HA-1 by reference strand mediated conformation analysis (RSCA)". Tissue Antigens 56 (1): 69–76. doi:10.1034/j.1399-0039.2000.560109.x. PMID 10958358.
Kaminski WE, Piehler A, Schmitz G (2001). "Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene". Biochem. Biophys. Res. Commun. 278 (3): 782–789. doi:10.1006/bbrc.2000.3880. PMID 11095984.
Gillespie G, Mutis T, Schrama E et al. (2002). "HLA class I-minor histocompatibility antigen tetramers select cytotoxic T cells with high avidity to the natural ligand". Hematol. J. 1 (6): 403–10. doi:10.1038/sj/thj/6200065. PMID 11920221.
Fujii N, Hiraki A, Ikeda K et al. (2002). "Expression of minor histocompatibility antigen, HA-1, in solid tumor cells". Transplantation 73 (7): 1137–1141. doi:10.1097/00007890-200204150-00022. PMID 11965046.
Mutis T, Blokland E, Kester M et al. (2002). "Generation of minor histocompatibility antigen HA-1-specific cytotoxic T cells restricted by nonself HLA molecules: a potential strategy to treat relapsed leukemia after HLA-mismatched stem cell transplantation". Blood 100 (2): 547–552. doi:10.1182/blood-2002-01-0024. PMID 12091347.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Wilke M, Dolstra H, Maas F et al. (2004). "Quantification of the HA-1 gene product at the RNA level; relevance for immunotherapy of hematological malignancies". Hematol. J. 4 (5): 315–320. doi:10.1038/sj.thj.6200318. PMID 14502255.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Kotzampasaki EM, Spyropoulou-Vlachou MS, Kalofoutis C et al. (2005). "Minor histocompatibility antigen HA-1 and HPA-5 polymorphisms in HLA-identical related bone marrow transplantation". Transplant. Proc. 36 (6): 1735–1738. doi:10.1016/j.transproceed.2004.06.007. PMID 15350465.
Mommaas B, Stegehuis-Kamp JA, van Halteren AG et al. (2005). "Cord blood comprises antigen-experienced T cells specific for maternal minor histocompatibility antigen HA-1". Blood 105 (4): 1823–1827. doi:10.1182/blood-2004-07-2832. PMID 15498856.
Harangi M, Kaminski WE, Fleck M et al. (2005). "Homozygosity for the 168His variant of the minor histocompatibility antigen HA-1 is associated with reduced risk of primary Sjögren's syndrome". Eur. J. Immunol. 35 (1): 305–317. doi:10.1002/eji.200425406. PMID 15593299.
Krishnan NS, Higgins RM, Lam FT et al. (2007). "HA-1 mismatch has significant effect in chronic allograft nephropathy in clinical renal transplantation". Transplant. Proc. 39 (5): 1439–1445. doi:10.1016/j.transproceed.2007.02.066. PMID 17580157.

HMHA1

References

Further reading