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major histocompatibility complex, class II, DR10
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| Haplotypes groups | DQA*01:DRB1*1001 |
| Structure (See HLA-DR) | |
| Identifiers |
alpha *0101
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| Symbol(s) | HLA-DRA |
| EBI-HLA | DRA*0101 |
| Identifiers |
beta 1 *1001
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| Symbol(s) | HLA-DRB1 |
| EBI-HLA | DRB1*1001 |
| Shared data | |
| Locus | chr.6 6p21.31 |
HLA-DR10 (DR10) is a HLA-DR serotype that recognizes the DRB1*1001 gene product.
Contents |
| DRB1* | DR10 | DR1 | Sample | |
| allele | % | % | % | size (N) |
| 1001 | 90 | 4 | 894 |
The serological reaction of DR10 is relatively good.
DR10 sertoype or cognate alleles are associated with: Lichen planus[2]
DRB1*1001 is associated with ovarian cancer[3] and invasive squamous cell cervical cancer (SCC)[4]
DRB1*1001:DQA1*01:DQB1*05 haplotype: Rheumatoid arthritis[5] The primary involvement appears to be DR10.
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DR10 Haplotypes
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| DRA | DRB1 | ||
|---|---|---|---|
| Haplotypes | *0101 | *1001 | |
| DQA1 | DQB1 | DRB1 | |
| Haplotypes | *0101 | *0501 | *1001 |
| HLA-A | HLA-B | DRB1 | |
| Haplotypes | *0000 | *0000 | *1001 |
HLA-DR10 is not genetically linked to DR51, DR52 or DR53, but is linked to HLA-DQ1 and DQ5 serotypes. One haplotype found in caucasians is the HLA-A1-B37-Cw6-DR10-DQ5.
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