HLA-A80
HLA-A80 (A80) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α80 subset of HLA-A α-chains. For A80, the alpha "A" chain are encoded by the HLA-A*80 allele group and the β-chain are encoded by B2M locus.[1] This group currently is dominated by A*8001. A80 and A*80 are almost synonymous in meaning.
A80 is more common in West Central Africa. A80 is the least common HLA-A allele group.
Serotype
A80 recognition of some HLA A*80 gene products[2]
| A*80 |
A80 |
A10 |
Sample |
| allele |
% |
% |
size (N) |
| *8001 |
36 |
10 |
505 |
A80 HLA-A80 typing is poor. Most typing is done with SSP-PCR. Most of 8001 are detected with "Blank" serotype..
Distribution
HLA A*8001 frequencies
| Study population |
Freq.
(in %)[3] |
| Senegal Niokholo Mandenka |
3.8 |
| Zambia Lusaka |
2.3 |
| Cameroon Bamileke |
1.9 |
| Mali Bandiagara |
1.5 |
| South Africa Tswana |
1.2 |
| Spain Minorca |
1.1 |
| Cameroon Bakola Pygmy |
1.0 |
| Burkina Faso Fulani |
1.0 |
| Trinidad Africans |
1.0 |
| Tunisia |
1.0 |
| Bulgaria |
0.9 |
| Cape Verde Southeastern I… |
0.8 |
| Guinea Bissau |
0.8 |
| USA African Americans |
0.8 |
| Peru Arequipa |
0.7 |
| Turkey class I |
0.7 |
| Cameroon Beti |
0.6 |
| Spain Catalonia Girona |
0.6 |
| USA Caucasians (3) |
0.6 |
| Brazil |
0.5 |
| Brazil Belo Horizonte |
0.5 |
| Brazil Pernambuco State |
0.5 |
| Croatia pop2 |
0.5 |
| Guatemala Mayans |
0.4 |
| Mongolia Buriat |
0.4 |
| Allele frequencies presented, only |
Further reading
- Torimiro JN, Carr JK, Wolfe ND, et al. (2006). "HLA class I diversity among rural rainforest inhabitants in Cameroon: identification of A*2612-B*4407 haplotype". Tissue Antigens 67 (1): 30–7. doi:10.1111/j.1399-0039.2005.00527.x. PMID 16451198.
- Sanchez-Mazas A, Steiner QG, Grundschober C, Tiercy JM (October 2000). "The molecular determination of HLA-Cw alleles in the Mandenka (West Africa) reveals a close genetic relationship between Africans and Europeans". Tissue Antigens 56 (4): 303–12. doi:10.1034/j.1399-0039.2000.560402.x. PMID 11098930. http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=0001-2815&date=2000&volume=56&issue=4&spage=303.
- Cao K, Moormann AM, Lyke KE, et al. (April 2004). "Differentiation between African populations is evidenced by the diversity of alleles and haplotypes of HLA class I loci". Tissue Antigens 63 (4): 293–325. doi:10.1111/j.0001-2815.2004.00192.x. PMID 15009803. http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=0001-2815&date=2004&volume=63&issue=4&spage=293.
- Torimiro JN, Carr JK, Wolfe ND, et al. (January 2006). "HLA class I diversity among rural rainforest inhabitants in Cameroon: identification of A*2612-B*4407 haplotype". Tissue Antigens 67 (1): 30–7. doi:10.1111/j.1399-0039.2005.00527.x. PMID 16451198.
- Crespí C, Milà J, Martínez-Pomar N, et al. (October 2002). "HLA polymorphism in a Majorcan population of Jewish descent: comparison with Majorca, Minorca, Ibiza (Balearic Islands) and other Jewish communities". Tissue Antigens 60 (4): 282–91. doi:10.1034/j.1399-0039.2002.600402.x. PMID 12472657. http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=0001-2815&date=2002&volume=60&issue=4&spage=282.
References