HLA-A66
HLA-A66 (A66) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α66 subset of HLA-A α-chains. For A66, the alpha "A" chain are encoded by the HLA-A*66 allele group and the β-chain are encoded by B2M locus.[1] A66 and A*66 are almost synonymous in meaning. A66 is a split antigen of the broad antigen serotype A10. A66 is a sister serotype of A25, A26, A34, and A43.
A66 is more common in Africa and Southwest Europe. A66 (A*6601) is believed to have been formed by a single gene conversion between another HLA-A and the A*2601 allele.[2].
Serotype
A66 recognition of some HLA A*66 gene products[3]
| A*66 |
A66 |
A10 |
A26 |
A34 |
Sample |
| allele |
% |
% |
% |
% |
size (N) |
| *6601 |
20 |
10 |
61 |
8 |
799 |
| *6602 |
38 |
10 |
4 |
18 |
205 |
| *6603 |
32 |
7 |
7 |
0 |
28 |
A66 serotyping is poor. A*6601 is also sometimes recognized by A25, and A*6602 is often recognized by A74.
A*6601 Frequencies
HLA A*6601 frequencies
|
|
freq |
| ref. |
Population |
(%) |
| [4] |
Cameroon Sawa |
7.7 |
| [4] |
Kenya Luo |
6.8 |
| [4] |
Cameroon Sawa |
7.7 |
| [4] |
Cameroon Bakola Pygmy |
5.8 |
| [4] |
Cameroon Baka Pygmy |
5.0 |
| [4] |
Kenya Nandi |
5.0 |
| [4] |
Zimbabwe Harare Shona |
0.2 |
| [4] |
Cameroon Baka Pygmy |
5.0 |
| [4] |
Cameroon Beti |
4.6 |
| [4] |
Cameroon Bamileke |
4.5 |
| [4] |
India West Bhils |
4.0 |
| [4] |
Zimbabwe Harere Shona |
3.8 |
| [4] |
Uganda Kampala |
3.8 |
| [4] |
India Mumbia Marathas |
2.5 |
| [4] |
Cape Verde Northwestern |
2.5 |
| [4] |
Czech republic |
2.4 |
| [4] |
Morocco Nador Metalsa |
2.1 |
| [4] |
Central Portugal |
2.0 |
| [4] |
India West Parsis |
2.0 |
| [4] |
South Africian Natal Zulu |
2.0 |
| [4] |
Kenya |
1.7 |
| [4] |
Tunisia Tunis |
1.7 |
| [4] |
Guinea Bissau |
1.5 |
| [4] |
Georgia Tibilisi |
1.4 |
| [4] |
Zambia Lusaka |
1.2 |
| [4] |
Italy Bergamo |
1.1 |
| [4] |
Pakistan Karachi Parsi |
1.1 |
| [4] |
Oman |
0.8 |
| [4] |
Sudanese |
0.8 |
| [4] |
Belgium |
0.5 |
| [4] |
Southeast France |
0.4 |
| [4] |
Mongolia Buriat |
0.4 |
| [4] |
Wales |
0.2 |
HLA A*6602 frequencies
|
|
freq |
| ref. |
Population |
(%) |
| [4] |
South Africian Natal Zulu |
1.5 |
| [4] |
Cameroon Yaounde |
1.1 |
| [4] |
Cameroon Bamileke |
0.6 |
| [4] |
Senegal Niokholo Mandenka |
0.5 |
| [4] |
Kenya Nandi |
0.4 |
| [4] |
Zimbabwe Harare Shona |
0.2 |
| [4] |
Wales |
0.03 |
| HLA A*6603 frequencies |
|
|
freq |
| ref. |
Population |
(%) |
| [4] |
Cameroon Pygmy Baka |
10.0 |
| [4] |
Cameroon Bakola Pygmy |
9.0 |
| [4] |
Cameroon Sawa |
7.7 |
| [4] |
CAR Mbenzele Pygmy |
2.8 |
| [4] |
Zimbabwe Harare Shona |
0.2 |
References
- ^ Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
- ^ Madrigal JA, Hildebrand WH, Belich MP, et al. (1993). "Structural diversity in the HLA-A10 family of alleles: correlations with serology". Tissue Antigens 41 (2): 72–80. doi:10.1111/j.1399-0039.1993.tb01982.x. PMID 8475492.
- ^ Allele Query Form IMGT/HLA - European Bioinformatics Institute
- ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ar as Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.