HLA-A43

HLA-A43
(MHC Class I, A cell surface antigen)
HLA-A43
-
Protein transmembrane receptor/ligand
Structure αβ heterodimer
Subunits HLA-A*4301, β2-microglobulin
Older names "A10"
-
subtype allele Available structures
A43 *4301
Alleles link-out to IMGT/HLA database at EBI

HLA-A43 (A43) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α43 subset of HLA-A α-chains. For A43, the alpha "A" chain are encoded by the HLA-A*43 allele group and the β-chain are encoded by B2M locus.[1] This group currently is dominated by A*4301. A43 and A*43 are almost synonymous in meaning. A43 is a split antigen of the broad antigen serotype A10. A43 is a sister serotype of A25, A26, A34, and A66.

Further information: HLA serotypes explained

A43 is more common in Africa and SouthWest Asia. A43 is believed to have been formed by a single gene conversion between another HLA-A and the A*2601 allele.[2].

Serotype

A43 recognition of some HLA A*43 gene products[3]
A*43 A43 A26 Sample
allele  %  % size (N)
*4301 0 35 9

A43 serotyping is poor.


Distribution

HLA A*4301 frequencies
freq
ref. Population (%)
[4] South Africa Tswana 4.9
[4] South Africian Natal Zulu 3.0
[4] China Yunnan Han 1.2
[4] Zambia Lusaka 1.2
[4] Pakistan Karachi Parsi 0.6
[4] India North Delhi 0.5
[4] Zimbabwe Harare Shona 0.4
[4] Italy 0.01
[4] China Shanghai 0.002

References

  1. ^ Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067. 
  2. ^ Madrigal JA, Hildebrand WH, Belich MP, et al. (1993). "Structural diversity in the HLA-A10 family of alleles: correlations with serology". Tissue Antigens 41 (2): 72–80. doi:10.1111/j.1399-0039.1993.tb01982.x. PMID 8475492. 
  3. ^ Allele Query Form IMGT/HLA - European Bioinformatics Institute
  4. ^ a b c d e f g h i Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660. 

HLA-A · A1 · A2 · A3 · A9 (A23 · A24) · A10 (A25 · A26 · A34 · A43 · A66) · A11 · A19 (A29 · A30 · A31 · A32 · A33 · A74) · A28 (A68 · A69) · A36 · A80