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HLA-A30
(MHC Class I, A cell surface antigen) |
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| HLA-A30 | ||||
| - | ||||
| Protein | transmembrane receptor/ligand | |||
| Structure | αβ heterodimer | |||
| Subunits | HLA-A*30--, β2-microglobulin | |||
| Older names | "A19" | |||
| - | ||||
| subtype | allele | Available structures | ||
| A30.3 | *3001 | |||
| A30.2 | *3002 | |||
| rare alleles | ||||
| A30.4 | *3004 | |||
| Alleles link-out to IMGT/HLA database at EBI | ||||
HLA-A30 (A30) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α30 subset of HLA-A α-chains. For A30, the alpha "A" chain are encoded by the HLA-A*30 allele group and the β-chain are encoded by B2M locus.[1] A30 and A*30 are almost synonymous in meaning. A30 is a split antigen of the broad antigen serotype A19. A30 is a sister serotype of A29, A31, A32, A33, and A74.
Contents |
| A*30 | A30 | A19 | A31 | Sample |
| allele | % | % | % | size (N) |
| *3001 | 89 | 1 | 3 | 3517 |
| *3002 | 93 | 1 | 2 | 2124 |
| *3004 | 94 | 0 | 0 | 85 |
| Study population | Freq. (in %)[3] |
| India West Coast Parsis | 16.0 |
| Mali Bandiagara | 14.1 |
| Zambia Lusaka | 14.0 |
| South Africian Natal Zulu | 9.5 |
| Jordan Amman | 9.3 |
| Pakistan Kalash | 9.2 |
| Zimbabwe Harare Shona | 9.1 |
| China Beijing | 9.0 |
| Kenya | 8.4 |
| Sudanese | 6.8 |
| Kenya Luo | 6.4 |
| India Khandesh Pawra | 6.0 |
| Pakistan Pathan | 5.6 |
| Cameroon Yaounde | 5.5 |
| USA African America | 5.0 |
| Kenya Nandi | 4.8 |
| Tunisia | 4.1 |
| Cameroon Beti | 4.0 |
| China Inner Mongolia | 3.9 |
| Cameroon Sawa | 3.8 |
| China North Han | 3.8 |
| Guinea Bissau | 3.8 |
| Senegal Niokholo Mandenka | 3.8 |
| South Korea (3) | 3.5 |
| India North Delhi | 3.3 |
| Cameroon Bamileke | 3.2 |
| Pakistan Baloch | 3.2 |
| Uganda Kampala | 3.1 |
| Israel Arab Druse | 3.0 |
| China Qinghai Hui | 2.7 |
| USA Hispanic | 2.6 |
| Brazil | 2.5 |
| France South East | 2.3 |
| Iran Baloch | 2.2 |
| Saudi Arabia Guraiat and … | 2.1 |
| USA North American Native… | 2.1 |
| Portugal Centre | 2.0 |
| Romanian | 2.0 |
| Czech Republic | 1.9 |
| Taiwan Hakka | 1.8 |
| USA Asian | 1.8 |
| Brazil Terena | 1.7 |
| Georgia Tibilisi Kurds | 1.7 |
| USA Caucasians (3) | 1.7 |
| China South Han | 1.6 |
| Morocco Nador Metalsa Cla… | 1.4 |
| Croatia | 1.3 |
| Macedonia (4) | 1.2 |
| Mexico Mestizos | 1.2 |
| India Andhra Pradesh Goll… | 1.1 |
| Ireland Northern | 1.1 |
| Mexico Chihuahua State Ta… | 1.1 |
| Mongolia Buriat | 1.1 |
| Pakistan Brahui | 1.1 |
| Portugal North | 1.1 |
| Thailand | 1.1 |
| Allele frequencies presented, only | |
| Study population | Freq. (in %)[3] |
| Zambia Lusaka | 23.3 |
| Zimbabwe Harare Shona | 14.7 |
| Senegal Niokholo Mandenka | 12.4 |
| Cameroon Beti | 9.5 |
| Morocco 'Berber' Nador Me… | 8.9 |
| South Africian Natal Zulu | 8.5 |
| Cameroon Sawa | 7.7 |
| Cameroon Bamileke | 7.1 |
| Cameroon Yaounde | 6.0 |
| Kenya Luo | 5.9 |
| USA African Americans (3) | 5.8 |
| Tunisia | 5.6 |
| Cameroon Pygmy Baka | 5.0 |
| Mexico Guadalajara Mestiz… | 4.9 |
| Oman | 4.2 |
| Pakistan Baloch | 4.0 |
| Uganda Kampala | 4.0 |
| Kenya Nandi | 3.7 |
| Mali Bandiagara | 3.4 |
| Pakistan Brahui | 3.4 |
| USA Hispanic | 3.4 |
| Guinea Bissau | 3.1 |
| USA South Texas Hispanics | 3.0 |
| Iran Baloch | 2.8 |
| Sudanese | 2.8 |
| Brazil | 2.5 |
| Portugal Centre | 2.0 |
| Saudi Arabia Guraiat and … | 1.9 |
| USA North American Native… | 1.9 |
| Georgia Tibilisi Kurds | 1.7 |
| Belgium | 1.6 |
| France South East | 1.2 |
| Ireland Northern | 1.2 |
| Macedonia | 1.2 |
| Pakistan Burusho | 1.1 |
| USA Caucasian Bethesda | 1.1 |
| Allele frequencies presented, only | |
A*3002 alters Type 1 diabetes risk[4]
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