HK3

Hexokinase 3 (white cell)

Identifiers

HK3; HKIII; HXK3

External IDs

OMIM: 142570 MGI: 2670962 HomoloGene: 55633 GeneCards: HK3 Gene

2.7.1.1

Gene Ontology
Molecular function	• nucleotide binding • glucokinase activity • hexokinase activity • hexokinase activity • ATP binding • kinase activity • transferase activity • enzyme binding • hormone binding
Cellular component	• mitochondrion • cytosol • membrane • protein complex
Biological process	• carbohydrate metabolic process • glycolysis • hexose transport • glucose transport • glucose 6-phosphate metabolic process • transmembrane transport
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 5:
176.31 – 176.33 Mb

Chr 13:
55.11 – 55.12 Mb

PubMed search

[1]

[2]

Hexokinase 3 also known as HK3 is an enzyme which in humans is encoded by the HK2 gene.^[1]^[2]

Function

Hexokinases phosphorylate glucose to produce glucose 6-phosphate, thus committing glucose to the glycolytic pathway. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose 6-phosphate.^[3]

References

^ Furuta H, Nishi S, Le Beau MM, Fernald AA, Yano H, Bell GI (August 1996). "Sequence of human hexokinase III cDNA and assignment of the human hexokinase III gene (HK3) to chromosome band 5q35.2 by fluorescence in situ hybridization". Genomics 36 (1): 206–9. doi:10.1006/geno.1996.0448. PMID 8812439.
^ Colosimo A, Calabrese G, Gennarelli M, Ruzzo AM, Sangiuolo F, Magnani M, Palka G, Novelli G, Dallapiccola B (1996). "Assignment of the hexokinase type 3 gene (HK3) to human chromosome band 5q35.3 by somatic cell hybrids and in situ hybridization". Cytogenet. Cell Genet. 74 (3): 187–8. doi:10.1159/000134409. PMID 8941369.
^ "Entrez Gene: HK3 hexokinase 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3101.

Reid S, Masters C (1985). "On the developmental properties and tissue interactions of hexokinase.". Mech. Ageing Dev. 31 (2): 197–212. doi:10.1016/S0047-6374(85)80030-0. PMID 4058069.
Rijksen G, Staal GE, Beks PJ, et al. (1982). "Compartmentation of hexokinase in human blood cells. Characterization of soluble and particulate enzymes.". Biochim. Biophys. Acta 719 (3): 431–7. PMID 7150652.
Adkins JN, Varnum SM, Auberry KJ, et al. (2002). "Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry.". Mol. Cell Proteomics 1 (12): 947–55. doi:10.1074/mcp.M200066-MCP200. PMID 12543931.
Palma F, Agostini D, Mason P, et al. (1996). "Purification and characterization of the carboxyl-domain of human hexokinase type III expressed as fusion protein.". Mol. Cell. Biochem. 155 (1): 23–9. doi:10.1007/BF00714329. PMID 8717435.
Povey S, Corney G, Harris H (1975). "Genetically determined polymorphism of a form of hexokinase, HK III, found in human leucocytes.". Ann. Hum. Genet. 38 (4): 407–15. doi:10.1111/j.1469-1809.1975.tb00630.x. PMID 1190733.
Anderson NL, Anderson NG (2002). "The human plasma proteome: history, character, and diagnostic prospects.". Mol. Cell Proteomics 1 (11): 845–67. doi:10.1074/mcp.R200007-MCP200. PMID 12488461.
He C, Kraft P, Chen C, et al. (2009). "Genome-wide association studies identify novel loci associated with age at menarche and age at natural menopause". Nat. Genet. 41 (6): 724–8. doi:10.1038/ng.385. PMC 2888798. PMID 19448621. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2888798.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Fonteyne P, Casneuf V, Pauwels P, et al. (2009). "Expression of hexokinases and glucose transporters in treated and untreated oesophageal adenocarcinoma". Histol. Histopathol. 24 (8): 971–7. PMID 19554504.
Sui D, Wilson JE (2000). "Interaction of insulin-like growth factor binding protein-4, Miz-1, leptin, lipocalin-type prostaglandin D synthase, and granulin precursor with the N-terminal half of type III hexokinase". Arch. Biochem. Biophys. 382 (2): 262–74. doi:10.1006/abbi.2000.2019. PMID 11068878.
Lowes W, Walker M, Alberti KG, Agius L (1998). "Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosis". Biochim. Biophys. Acta 1379 (1): 134–42. PMID 9468341.
Furuta H, Nishi S, Le Beau MM, et al. (1996). "Sequence of human hexokinase III cDNA and assignment of the human hexokinase III gene (HK3) to chromosome band 5q35.2 by fluorescence in situ hybridization". Genomics 36 (1): 206–9. doi:10.1006/geno.1996.0448. PMID 8812439.