HIST2H3C

Histone cluster 2, H3c

PDB rendering based on 1aoi.
Identifiers
Symbols HIST2H3C; H3; H3.2; H3/M; H3F2; H3FM; H3FN; HIST2H3A; HIST2H3D; MGC9629
External IDs OMIM142780 MGI2448355 HomoloGene110729 GeneCards: HIST2H3C Gene
Orthologs
Species Human Mouse
Entrez 126961 15077
Ensembl n/a ENSMUSG00000070392
UniProt Q71DI3 n/a
RefSeq (mRNA) XM_001124743 NM_178216.1
RefSeq (protein) XP_001124743 NP_835734.1
Location (UCSC) n/a Chr 3:
96.05 – 96.05 Mb
PubMed search [1] [2]

Histone H3.2 is a protein that in humans is encoded by the HIST2H3C gene.[1][2][3]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy.[3]

Interactions

HIST2H3C has been shown to interact with NCOA6.[4]

References

  1. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–498. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  2. ^ Marashi F, Helms S, Shiels A, Silverstein S, Greenspan DS, Stein G, Stein J (Jul 1986). "Enhancer-facilitated expression of prokaryotic and eukaryotic genes using human histone gene 5' regulatory sequences". Biochem Cell Biol 64 (4): 277–289. doi:10.1139/o86-039. PMID 3013246. 
  3. ^ a b "Entrez Gene: HIST2H3C histone cluster 2, H3c". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=126961. 
  4. ^ Goo, Young-Hwa; Sohn Young Chang, Kim Dae-Hwan, Kim Seung-Whan, Kang Min-Jung, Jung Dong-Ju, Kwak Eunyee, Barlev Nickolai A, Berger Shelley L, Chow Vincent T, Roeder Robert G, Azorsa David O, Meltzer Paul S, Suh Pan-Gil, Song Eun Joo, Lee Kong-Joo, Lee Young Chul, Lee Jae Woon (Jan. 2003). "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins". Mol. Cell. Biol. (United States) 23 (1): 140–149. doi:10.1128/MCB.23.1.140-149.2003. ISSN 0270-7306. PMC 140670. PMID 12482968. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=140670. 

Further reading