HIPK3

Homeodomain interacting protein kinase 3

Identifiers

HIPK3; DYRK6; FIST3; PKY; YAK1

External IDs

OMIM: 604424 MGI: 1314882 HomoloGene: 55923 GeneCards: HIPK3 Gene

2.7.11.1

Gene Ontology
Molecular function	• nucleotide binding • protein kinase activity • protein serine/threonine kinase activity • protein serine/threonine kinase activity • ATP binding
Cellular component	• nucleus • cytoplasm • PML body
Biological process	• regulation of transcription, DNA-dependent • protein phosphorylation • protein phosphorylation • apoptosis • anti-apoptosis • peptidyl-serine phosphorylation • peptidyl-threonine phosphorylation • negative regulation of JUN kinase activity
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
33.28 – 33.38 Mb

Chr 2:
104.27 – 104.33 Mb

PubMed search

[1]

[2]

Homeodomain-interacting protein kinase 3 is an enzyme that in humans is encoded by the HIPK3 gene.^[1]^[2]^[3]

References

^ Begley DA, Berkenpas MB, Sampson KE, Abraham I (Dec 1997). "Identification and sequence of human PKY, a putative kinase with increased expression in multidrug-resistant cells, with homology to yeast protein kinase Yak1". Gene 200 (1–2): 35–43. doi:10.1016/S0378-1119(97)00350-8. PMID 9373137.
^ Kim YH, Choi CY, Lee SJ, Conti MA, Kim Y (Nov 1998). "Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors". J Biol Chem 273 (40): 25875–9. doi:10.1074/jbc.273.40.25875. PMID 9748262.
^ "Entrez Gene: HIPK3 homeodomain interacting protein kinase 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10114.

Moilanen AM, Karvonen U, Poukka H et al. (1999). "Activation of Androgen Receptor Function by a Novel Nuclear Protein Kinase". Mol. Biol. Cell 9 (9): 2527–43. PMC 25523. PMID 9725910. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=25523.
Scaffidi C, Volkland J, Blomberg I et al. (2000). "Phosphorylation of FADD/ MORT1 at serine 194 and association with a 70-kDa cell cycle-regulated protein kinase". J. Immunol. 164 (3): 1236–42. PMID 10640736.
Nupponen NN, Visakorpi T (2000). "Assignment of the protein kinase homolog of YAK1 (HIPK3) to human chromosome band 11p13 by in situ hybridization". Cytogenet. Cell Genet. 87 (1–2): 102–3. doi:10.1159/000015404. PMID 10640824.
Dias Neto E, Correa RG, Verjovski-Almeida S et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16267.
Minty A, Dumont X, Kaghad M, Caput D (2000). "Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif". J. Biol. Chem. 275 (46): 36316–23. doi:10.1074/jbc.M004293200. PMID 10961991.
Rochat-Steiner V, Becker K, Micheau O et al. (2000). "Fist/Hipk3: A FAS/Fadd-Interacting Serine/Threonine Kinase That Induces Fadd Phosphorylation and Inhibits FAS-Mediated Jun Nh2-Terminal Kinase Activation". J. Exp. Med. 192 (8): 1165–74. doi:10.1084/jem.192.8.1165. PMC 2311455. PMID 11034606. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2311455.
Curtin JF, Cotter TG (2004). "JNK regulates HIPK3 expression and promotes resistance to Fas-mediated apoptosis in DU 145 prostate carcinoma cells". J. Biol. Chem. 279 (17): 17090–100. doi:10.1074/jbc.M307629200. PMID 14766760.
Colland F, Jacq X, Trouplin V et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442148.
Rush J, Moritz A, Lee KA et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
Venables JP, Bourgeois CF, Dalgliesh C et al. (2005). "Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon". Hum. Mol. Genet. 14 (16): 2289–303. doi:10.1093/hmg/ddi233. PMID 16000324.
Taylor TD, Noguchi H, Totoki Y et al. (2006). "Human chromosome 11 DNA sequence and analysis including novel gene identification". Nature 440 (7083): 497–500. doi:10.1038/nature04632. PMID 16554811.
Lan HC, Li HJ, Lin G et al. (2007). "Cyclic AMP Stimulates SF-1-Dependent CYP11A1 Expression through Homeodomain-Interacting Protein Kinase 3-Mediated Jun N-Terminal Kinase and c-Jun Phosphorylation". Mol. Cell. Biol. 27 (6): 2027–36. doi:10.1128/MCB.02253-06. PMC 1820514. PMID 17210646. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1820514.

HIPK3

References

Further reading