HIPK1
Homeodomain-interacting protein kinase 1 is an enzyme that in humans is encoded by the HIPK1 gene.[1]
The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms.[1]
Interactions
HIPK1 has been shown to interact with P53.[2]
References
- ^ a b "Entrez Gene: HIPK1 homeodomain interacting protein kinase 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=204851.
- ^ Kondo, Seiji; Lu Ying, Debbas Michael, Lin Athena W, Sarosi Ildiko, Itie Annick, Wakeham Andrew, Tuan JoAnn, Saris Chris, Elliott Gary, Ma Weili, Benchimol Samuel, Lowe Scott W, Mak Tak Wah, Thukral Sushil K (Apr. 2003). "Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1)". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (9): 5431–6. doi:10.1073/pnas.0530308100. ISSN 0027-8424. PMC 154362. PMID 12702766. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=154362.
Further reading
- Ishikawa K, Nagase T, Suyama M et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
- Kim YH, Choi CY, Lee SJ et al. (1998). "Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors". J. Biol. Chem. 273 (40): 25875–9. doi:10.1074/jbc.273.40.25875. PMID 9748262.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Ecsedy JA, Michaelson JS, Leder P (2003). "Homeodomain-Interacting Protein Kinase 1 Modulates Daxx Localization, Phosphorylation, and Transcriptional Activity". Mol. Cell. Biol. 23 (3): 950–60. doi:10.1128/MCB.23.3.950-960.2003. PMC 140690. PMID 12529400. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=140690.
- Kondo S, Lu Y, Debbas M et al. (2003). "Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1)". Proc. Natl. Acad. Sci. U.S.A. 100 (9): 5431–6. doi:10.1073/pnas.0530308100. PMC 154362. PMID 12702766. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=154362.
- Song JJ, Lee YJ (2004). "Role of the ASK1-SEK1-JNK1-HIPK1 signal in Daxx trafficking and ASK1 oligomerization". J. Biol. Chem. 278 (47): 47245–52. doi:10.1074/jbc.M213201200. PMID 12968034.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Colland F, Jacq X, Trouplin V et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442148.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Li X, Zhang R, Luo D et al. (2005). "Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation". J. Biol. Chem. 280 (15): 15061–70. doi:10.1074/jbc.M414262200. PMID 15701637.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.