HHIP

Hedgehog interacting protein

Rendering based on PDB 2WFT.

Available structures
PDB	2WFT, 2WFX, 2WG3, 2WG4, 3HO3, 3HO4, 3HO5

Identifiers

Symbols

HHIP; FLJ20992; FLJ90230; HIP

External IDs

OMIM: 606178 MGI: 1341847 HomoloGene: 32469 GeneCards: HHIP Gene

Gene Ontology
Molecular function	• catalytic activity • protein binding • zinc ion binding • metal ion binding
Cellular component	• extracellular region • cytoplasm • plasma membrane • integral to plasma membrane • cell surface
Biological process	• neuroblast proliferation • organ morphogenesis • dorsal/ventral pattern formation • negative regulation of signal transduction • regulation of fibroblast growth factor receptor signaling pathway • negative regulation of smoothened signaling pathway • epithelial tube branching involved in lung morphogenesis
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 4:
145.57 – 145.67 Mb

Chr 8:
82.49 – 82.58 Mb

PubMed search

[1]

[2]

Hedgehog-interacting protein is a protein that in humans is encoded by the HHIP gene.^[1]^[2]^[3]

This gene encodes a protein similar to the mouse hedgehog-interacting protein, a regulatory component of the Hedgehog signaling pathway. Members of the hedgehog family are evolutionarily conserved proteins which are involved in many fundamental processes in embryonic development, including anteroposterior patterns of limbs and regulation of left-right asymmetry.^[3]

References

^ Bak M, Hansen C, Friis Henriksen K, Tommerup N (Jul 2001). "The human hedgehog-interacting protein gene: structure and chromosome mapping to 4q31.21→q31.3". Cytogenet Cell Genet 92 (3–4): 300–3. doi:10.1159/000056918. PMID 11435703.
^ Ingham PW, McMahon AP (Dec 2001). "Hedgehog signaling in animal development: paradigms and principles". Genes Dev 15 (23): 3059–87. doi:10.1101/gad.938601. PMID 11731473.
^ ^a ^b "Entrez Gene: HHIP hedgehog interacting protein". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64399.

Chuang PT, McMahon AP (1999). "Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein". Nature 397 (6720): 617–21. doi:10.1038/17611. PMID 10050855.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Olsen CL, Hsu PP, Glienke J, et al. (2004). "Hedgehog-interacting protein is highly expressed in endothelial cells but down-regulated during angiogenesis and in several human tumors". BMC Cancer 4: 43. doi:10.1186/1471-2407-4-43. PMC 512291. PMID 15294024. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=512291.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Kayed H, Kleeff J, Esposito I, et al. (2005). "Localization of the human hedgehog-interacting protein (Hip) in the normal and diseased pancreas". Mol. Carcinog. 42 (4): 183–92. doi:10.1002/mc.20088. PMID 15754313.
Martin ST, Sato N, Dhara S, et al. (2006). "Aberrant methylation of the Human Hedgehog interacting protein (HHIP) gene in pancreatic neoplasms". Cancer Biol. Ther. 4 (7): 728–33. PMID 15970691.

Signaling pathway: hedgehog signaling pathway

Ligands	Sonic hedgehog · Indian hedgehog · Desert hedgehog

Receptor	Patched · Smoothened

Transcription factor	GLI1 · GLI2 · GLI3

Other	HHIP · HHAT

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

HHIP

References

Further reading