HHAT

hedgehog acyltransferase
Identifiers
Symbol HHAT
Alt. symbols FLJ10724, MART-2, MART2, GUP2
Entrez 55733
HUGO 18270
OMIM 605743
RefSeq NM_018194
UniProt Q5VTY9
Other data
EC number 2.3.1.-
Locus Chr. 1 q32

HHAT (hedgehog acyltransferase) also known as HHAT is a human gene.[1]

The HHAT gene encodes an enzyme that catalyzes N-terminal palmitoylation of sonic hedgehog. Mutations in HHAT produce a phenotype that is similar to loss of hedgehog function. Finally the HHAT protein shares a short but significant sequence similarity to membrane-bound O-acyltransferases.[2]

References

  1. ^ Kawakami Y, Wang X, Shofuda T, Sumimoto H, Tupesis J, Fitzgerald E, Rosenberg S (February 2001). "Isolation of a new melanoma antigen, MART-2, containing a mutated epitope recognized by autologous tumor-infiltrating T lymphocytes". J. Immunol. 166 (4): 2871–7. PMID 11160356. http://www.jimmunol.org/cgi/content/abstract/166/4/2871. 
  2. ^ Chamoun Z, Mann RK, Nellen D, von Kessler DP, Bellotto M, Beachy PA, Basler K (September 2001). "Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal". Science 293 (5537): 2080–4. doi:10.1126/science.1064437. PMID 11486055. 

External links

Ligands
Receptor
Transcription factor
GLI1 · GLI2 · GLI3
Other
HHIP · HHAT
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)