HERC5
Probable E3 ubiquitin-protein ligase HERC5 is an enzyme that in humans is encoded by the HERC5 gene.[1][2]
This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4.[2]
Interactions
HERC5 has been shown to interact with NME2[3] and Cyclin E1.[1]
References
- ^ a b Mitsui K, Nakanishi M, Ohtsuka S, Norwood TH, Okabayashi K, Miyamoto C, Tanaka K, Yoshimura A, Ohtsubo M (Jan 2000). "A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins". Biochem Biophys Res Commun 266 (1): 115–22. doi:10.1006/bbrc.1999.1777. PMID 10581175.
- ^ a b "Entrez Gene: HERC5 hect domain and RLD 5". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51191.
- ^ Hochrainer, K; Kroismayr R, Baranyi U, Binder B R, Lipp J (Jul. 2008). "Highly homologous HERC proteins localize to endosomes and exhibit specific interactions with hPLIC and Nm23B". Cell. Mol. Life Sci. (Switzerland) 65 (13): 2105–17. doi:10.1007/s00018-008-8148-5. ISSN 1420-682X. PMID 18535780.
Further reading
- Salon C, Merdzhanova G, Brambilla C, et al. (2007). "E2F-1, Skp2 and cyclin E oncoproteins are upregulated and directly correlated in high-grade neuroendocrine lung tumors.". Oncogene 26 (48): 6927–36. doi:10.1038/sj.onc.1210499. PMID 17471231.
- Takeuchi T, Inoue S, Yokosawa H (2006). "Identification and Herc5-mediated ISGylation of novel target proteins.". Biochem. Biophys. Res. Commun. 348 (2): 473–7. doi:10.1016/j.bbrc.2006.07.076. PMID 16884686.
- Wong JJ, Pung YF, Sze NS, Chin KC (2006). "HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets". Proc. Natl. Acad. Sci. U.S.A. 103 (28): 10735–40. doi:10.1073/pnas.0600397103. PMC 1484417. PMID 16815975. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1484417.
- Dastur A, Beaudenon S, Kelley M, et al. (2006). "Herc5, an interferon-induced HECT E3 enzyme, is required for conjugation of ISG15 in human cells". J. Biol. Chem. 281 (7): 4334–8. doi:10.1074/jbc.M512830200. PMID 16407192.
- Hochrainer K, Mayer H, Baranyi U, et al. (2005). "The human HERC family of ubiquitin ligases: novel members, genomic organization, expression profiling, and evolutionary aspects". Genomics 85 (2): 153–64. doi:10.1016/j.ygeno.2004.10.006. PMID 15676274.
- Kroismayr R, Baranyi U, Stehlik C, et al. (2005). "HERC5, a HECT E3 ubiquitin ligase tightly regulated in LPS activated endothelial cells". J. Cell. Sci. 117 (Pt 20): 4749–56. doi:10.1242/jcs.01338. PMID 15331633.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Xu XR, Huang J, Xu ZG, et al. (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–94. doi:10.1073/pnas.241522398. PMC 64988. PMID 11752456. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=64988.