HDAC1

Histone deacetylase 1
Identifiers
Symbols HDAC1; DKFZp686H12203; GON-10; HD1; RPD3; RPD3L1
External IDs OMIM: 601241 MGI: 108086 HomoloGene: 68426 GeneCards: HDAC1 Gene
EC number 3.5.1.98
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 3065 433759
Ensembl ENSG00000116478 ENSMUSG00000028800
UniProt Q13547 O09106
RefSeq (mRNA) NM_004964.2 NM_008228.2
RefSeq (protein) NP_004955.2 NP_032254.1
Location (UCSC) Chr 1:
32.76 – 32.8 Mb		 Chr 4:
129.19 – 129.22 Mb
PubMed search [1] [2]

Histone deacetylase 1 is an enzyme that in humans is encoded by the HDAC1 gene.[1]

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2 MTA2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.[2]

Contents

See also

Interactions

HDAC1 has been shown to interact with RAD9A,[3] DNMT3L,[4][5] MTA1,[6][7] FKBP3,[8] CDC20,[9] CDH1,[9] Host cell factor C1,[10] BUB3,[9] Nuclear receptor co-repressor 2,[11][12] IKZF1,[13][14] Prohibitin,[15][16] EVI1,[17][18] DDX5,[19] DNMT3A,[20] Mothers against decapentaplegic homolog 2,[21] Histone deacetylase 2,[22][6][23][24][25][26][11][27][28][29][30][31][32] MIER1,[33] SIN3A,[34][6][35][36][37][38][39][28][40][29][30][41][42][43] Death-associated protein 6,[44] Androgen receptor,[45] HMG20B,[22] HUS1,[3] IFRD1,[46] MLL,[47] ING1,[48][43] MyoD,[49][50] GATA1,[51] SPEN,[52] Mad1,[9] Promyelocytic leukemia protein,[53][54] CHD3,[29][43] Homeobox protein TGIF1,[55][56] Retinoblastoma-like protein 2,[57][58] Retinoblastoma-like protein 1,[59][57] CHD4,[6][37][29] RCOR1,[22][39] RBBP7,[6][60][28][31] RFC1,[61] Retinoblastoma protein,[62][63][49][16][64][59][57] RBBP4,[34][6][65][37][39][66][60][28][40][30][31] EED,[32] PHF21A,[22][67] SIN3B,[28][13] RELA,[68][69][27] NFKB1,[69] BUB1B,[9] Mdm2,[70] SATB1,[41] HSPA4,[25] SUV39H1,[71] BUB1,[9] Methyl-CpG-binding domain protein 2,[72][60][28] Zinc finger and BTB domain-containing protein 16,[73][74][75] DDX17,[19] BCL6,[74][76] SUDS3,[35][77] SAP30,[78][79][28][80][81][43] Sp1 transcription factor,[82][83][40][84] MTA2,[6][39][28][41] PCNA,[85] CBFA2T3,[86][87] TOP2B,[88][89] MBD3,[90][28][91] CTBP1,[92][55][93] TOP2A,[88][89] EZH2,[32]BTG2, [94] and COUP-TFII.[95]

References

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