HBZ

Hemoglobin, zeta

PDB rendering based on 1jeb.
Identifiers
Symbols HBZ;
External IDs OMIM142310 MGI96019 HomoloGene110705 GeneCards: HBZ Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 3050 15126
Ensembl ENSG00000130656 ENSMUSG00000055609
UniProt P02008 Q78PA4
RefSeq (mRNA) NM_005332 NM_010405.4
RefSeq (protein) NP_005323 NP_034535.1
Location (UCSC) Chr 16:
0.2 – 0.2 Mb
Chr 11:
32.18 – 32.18 Mb
PubMed search [1] [2]

Hemoglobin subunit zeta is a protein that in humans is encoded by the HBZ gene.[1][2]

Zeta-globin is an alpha-like hemoglobin. The zeta-globin polypeptide is synthesized in the yolk sac of the early embryo, while alpha-globin is produced throughout fetal and adult life. The zeta-globin gene is a member of the human alpha-globin gene cluster that includes five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 -alpha-1 - theta1 - 3'.[2]

References

  1. ^ Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (May 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood 73 (5): 1081–104. PMID 2649166. 
  2. ^ a b "Entrez Gene: HBZ hemoglobin, zeta". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3050. 

Further reading