HBG2

Hemoglobin, gamma G

PDB rendering based on 1fdh.
Identifiers
Symbols HBG2;
External IDs OMIM: 142250 HomoloGene: 73883 GeneCards: HBG2 Gene
Orthologs
Species Human Mouse
Entrez 3048 15132
Ensembl ENSG00000196565 ENSMUSG00000052217
UniProt P69892 n/a
RefSeq (mRNA) NM_000184.2 NM_008219.3
RefSeq (protein) NP_000175.1 NP_032245.1
Location (UCSC) Chr 11:
5.27 – 5.67 Mb		 Chr 7:
110.99 – 110.99 Mb
PubMed search [1] [2]

Hemoglobin subunit gamma-2 is a protein that in humans is encoded by the HBG2 gene.[1] The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'- epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.[2]

References

  1. ^ Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (May 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood 73 (5): 1081–104. PMID 2649166. 
  2. ^ "Entrez Gene: HBG2 hemoglobin, gamma G". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3048. 

Further reading

  • Gelinas R, Yagi M, Endlich B, et al. (1985). "Sequences of G gamma, A gamma, and beta genes of the Greek (A gamma) HPFH mutant: evidence for a distal CCAAT box mutation in the A gamma gene.". Prog. Clin. Biol. Res. 191: 125–39. PMID 2413469. 
  • Anderson NL, Anderson NG (2003). "The human plasma proteome: history, character, and diagnostic prospects.". Mol. Cell Proteomics 1 (11): 845–67. doi:10.1074/mcp.R200007-MCP200. PMID 12488461. 
Globins
Subunits

Alpha locus on 16: α (HBA1, HBA2) · ζ (HBZ) · θ (HBQ1) · μ (HBM)

Beta locus on 11: β (HBB) · δ (HBD) · γ (HBG1, HBG2) · ε (HBE1)

stages of development: HbA (α2β2) · HbA2 (α2δ2) · HbF/Fetal (α2γ2) · HbE Gower 2 (α2ε2) · HbE Gower 1 (ζ2ε2)

pathology: HbH (β4) · Barts (γ4) · HbS (α2βS2) · HbC (α2βC2) · HbE (α2βE2)
Compounds
Other human
Nonhuman
Other
Other
see also disorders of globin and globulin proteins

M: MYL

cell/phys (coag, heme, immu, gran), csfs

rbmg/mogr/tumr/hist, sysi/epon, btst

drug (B1/2/3+5+6), btst, trns