| H2A histone family, member B2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | H2AFB2; | ||||||||||||
| External IDs | MGI: 3644980 GeneCards: H2AFB2 Gene | ||||||||||||
|
|||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 474381 | 624153 | |||||||||||
| Ensembl | ENSG00000198307 | ENSMUSG00000082482 | |||||||||||
| UniProt | P0C5Z0 | n/a | |||||||||||
| RefSeq (mRNA) | NM_001017991 | XM_888672 | |||||||||||
| RefSeq (protein) | NP_001017991 | XP_893765 | |||||||||||
| Location (UCSC) | Chr X: 154.61 – 154.61 Mb |
Chr X: 113.79 – 113.8 Mb |
|||||||||||
| PubMed search | [1] | [2] | |||||||||||
Histone H2A-Bbd type 2/3 also known as H2A Barr body-deficient is a histone protein that in humans is encoded by the H2AFB2 gene (H2A histone family, member B1).[1]
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. This gene is part of a region that is repeated three times on chromosome X, once in intron 22 of the F8 gene and twice closer to the Xq telomere. This record represents the middle copy.[1]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.