H1 histone family, member O, oocyte-specific | |||||||||||||
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Identifiers | |||||||||||||
Symbols | H1FOO; MGC50807; osH1 | ||||||||||||
External IDs | MGI: 2176207 HomoloGene: 51377 GeneCards: H1FOO Gene | ||||||||||||
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Orthologs | |||||||||||||
Species | Human | Mouse | |||||||||||
Entrez | 132243 | 171506 | |||||||||||
Ensembl | ENSG00000178804 | ENSMUSG00000042279 | |||||||||||
UniProt | Q8IZA3 | Q8VIK3 | |||||||||||
RefSeq (mRNA) | NM_153833 | NM_138311.2 | |||||||||||
RefSeq (protein) | NP_722575 | NP_612184.1 | |||||||||||
Location (UCSC) | Chr 3: 129.26 – 129.27 Mb |
Chr 6: 115.89 – 115.9 Mb |
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PubMed search | [1] | [2] |
Histone H1oo is a protein that in humans is encoded by the H1FOO gene.[1][2]
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a member of the histone H1 family. This gene contains introns, unlike most histone genes. The protein encoded is a member of the histone H1 family. The related mouse gene is expressed only in oocytes.[2]
It incorporates into sperm chromatin after fertilisation.[3]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.