Geiparvarin

Geiparvarin
IUPAC name

7-{[(2E)-3-(5,5-dimethyl-4-oxo-4,5-dihydrofuran- 2-yl)but-2-en-1-yl]oxy}-2H-chromen-2-one
Identifiers
CAS number 36413-91-9
PubChem 5910585
MeSH Geiparvarin
Jmol-3D images Image 1
Properties
Molecular formula C19H18O5
Molar mass 326.343 g/mol
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Geiparvarin is a coumarin derivative found in the leaves of the Australian Willow (Geijera parviflora).[1] It is a monoamine oxidase inhibitor.[2]

Several analogues of geiparvarin have been studied for antitumor properties.[3][4][5]

References

  1. ^ Lahey FN, Macleod JK (September 1967). "The coumarins of Geijera parviflora Lindl". Aust J Chem 20 (9): 1943–55. doi:10.1071/CH9671943. 
  2. ^ Carotti A, Carrieri A, Chimichi S et al. (December 2002). "Natural and synthetic geiparvarins are strong and selective MAO-B inhibitors. Synthesis and SAR studies". Bioorg. Med. Chem. Lett. 12 (24): 3551–3555. doi:10.1016/S0960-894X(02)00798-9. PMID 12443774. http://linkinghub.elsevier.com/retrieve/pii/S0960894X02007989. 
  3. ^ Baraldi PG, Guarneri M, Manfredini S, Simoni D, Balzarini J, De Clercq E (February 1989). "Synthesis and cytostatic activity of geiparvarin analogues". J Med Chem 32 (2): 284–288. doi:10.1021/jm00122a002. PMID 2913291. 
  4. ^ Valenti P, Rampa A, Recanatini M et al. (September 1997). "Synthesis, cytotoxicity and SAR of simple geiparvarin analogues". Anticancer Drug Des 12 (6): 443–51. PMID 9311554. 
  5. ^ Viola G, Vedaldi D, dall'Acqua F et al. (September 2004). "Synthesis, cytotoxicity, and apoptosis induction in human tumor cells by geiparvarin analogues". Chem Biodivers 1 (9): 1265–1280. doi:10.1002/cbdv.200490089. PMID 17191904.