Gadobutrol

Gadobutrol
Systematic (IUPAC) name
gadolinium(III) 2,2',2''-(10-((2R,3S)-1,3,4-trihydroxybutan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate
Clinical data
AHFS/Drugs.com International Drug Names
Licence data US FDA:link
Pregnancy cat. C(US)
Legal status POM (UK) ℞-only (US)
Routes IV
Identifiers
CAS number 138071-82-6 Y
ATC code V08CA09
PubChem CID 72057
DrugBank DB06703
UNII 1BJ477IO2L Y
KEGG D07420 Y
ChEMBL CHEMBL1628503 N
Chemical data
Formula C18H31GdN4O9 
Mol. mass 604.710 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Gadobutrol (INN) (Gd-DO3A-butrol) is a gadolinium-based MRI contrast agent (GBCA).

It received marketing approval in Canada[1] and in the United States.[2][3][4]

As of 2007, it was the only GBCA approved at 1.0 molar concentrations.[5]

Gadobutrol is marketed by Bayer Schering Pharma as Gadovist, and by Bayer HealthCare Pharmaceuticals as Gadavist.[6]

References

  1. ^ Cheng, KT (2007). Gadobutrol. Bethesda, MD: National Center for Biotechnology Information (NCBI). PMID 20641787. NBK23589. http://www.ncbi.nlm.nih.gov/books/NBK23589/pdf/Gadobutrol.pdf. 
  2. ^ http://bayerimaging.com/products/gadavist/index.php
  3. ^ "FDA approves imaging agent for central nervous system scans" (Press release). U.S. Food and Drug Administration (FDA). March 15, 2011. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm247207.htm. Retrieved March 31, 2011. 
  4. ^ "U.S. FDA Approves Bayer’s Gadavist (Gadobutrol) Injection for MRI of the Central Nervous System" (Press release). Bayer HealthCare Pharmaceuticals. March 14, 2011. http://pharma.bayer.com/scripts/pages/en/news_room/news_room/news_room105.php. Retrieved March 31, 2011. 
  5. ^ "Gadobutrol 1.0-molar in Cardiac Magnetic Resonance Imaging (MRI) - Further Enhancing the Capabilities of Contrast-enhanced MRI in Ischaemic and Non-ischaemic Heart Disease?"
  6. ^ "Gadavist full prescribing information". http://labeling.bayerhealthcare.com/html/products/pi/gadavist_PI.pdf. Retrieved 2011-03-14. 
X-ray and CT
Iodinated,
Water soluble
Nephrotropic,
high osmolar
Nephrotropic,
low osmolar
Hepatotropic
Iodinated,
Water insoluble
Non-iodinated
MRI
Ferumoxsil • Ferristene • Iron oxide, nanoparticles
Other
Ultrasound