GadY

GadY
Predicted secondary structure and sequence conservation of GadY
Identifiers
Symbol GadY
Alt. Symbols IS183
Rfam RF00122
Other data
RNA type Gene; sRNA
Domain(s) Bacteria
SO 0001263

GadY RNA (previously named IS183 in [1]) is a non-coding RNA. The GadY gene is located on between and on the opposite strand to the GadX and GadW genes. GadY can form base pairs with the 3' UTR of its target mRNA gadX, this pairing is thought to confer increased stability to the transcript, allowing accumulation of gadX (a transcriptional regulator of the acid response) and therefore increased expression of downstream acid resistance genes.[2] The GadY gene produces three overlapping transcripts that differ in length. The long form is 105 nucleotides in length and two processed versions are 59 and 90 nucleotides in length. It has been shown that all three forms of GadY bind to the Hfq protein.[2]

References

  1. ^ Tjaden, B; Saxena RM, Stolyar S, Haynor DR, Kolker E, Rosenow C (2002). "Transcriptome analysis of Escherichia coli using high-density oligonucleotide probe arrays". Nucleic Acids Res 30 (17): 3732–3738. doi:10.1093/nar/gkf505. PMC 137427. PMID 12202758. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=137427. 
  2. ^ a b Opdyke JA, Kang JG, Storz G (2004). "GadY, a small-RNA regulator of acid response genes in Escherichia coli". J. Bacteriol. 186 (20): 6698–6705. doi:10.1128/JB.186.20.6698-6705.2004. PMC 522195. PMID 15466020. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=522195. 

External links