Gabexate

Gabexate
Systematic (IUPAC) name
ethyl 4-[6-(diaminomethylideneamino)hexanoyloxy]benzoate
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 39492-01-8 Y
ATC code None
PubChem CID 3447
UNII 4V7M9137X9 Y
KEGG D08004 Y
ChEMBL CHEMBL87563 N
Chemical data
Formula C16H23N3O4 
Mol. mass 311.37 g/mol
 N(what is this?)  (verify)

Gabexate is a serine protease inhibitor which is used therapeutically (as gabexate mesilate) in the treatment of pancreatitis, disseminated intravascular coagulation[1], and as a regional anticoagulant for haemodialysis.[2]

References

  1. ^ Yuksel M, Okajima K, Uchiba M, Okabe H (2003). "Gabexate mesilate, a synthetic protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production by inhibiting activation of both nuclear factor-kappaB and activator protein-1 in human monocytes". J. Pharmacol. Exp. Ther. 305 (1): 298–305. doi:10.1124/jpet.102.041988. PMID 12649382. http://jpet.aspetjournals.org/cgi/reprint/305/1/298.pdf. 
  2. ^ Cavallini G, Tittobello A, Frulloni L, Masci E, Mariana A, Di Francesco V (1996). "Gabexate for the prevention of pancreatic damage related to endoscopic retrograde cholangiopancreatography. Gabexate in digestive endoscopy--Italian Group". N. Engl. J. Med. 335 (13): 919–23. doi:10.1056/NEJM199609263351302. PMID 8786777. http://content.nejm.org/cgi/reprint/335/13/919.pdf.