GZMB

Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)

PDB rendering based on 1fq3.
Identifiers
Symbols GZMB; CCPI; CGL-1; CGL1; CSP-B; CSPB; CTLA1; CTSGL1; HLP; SECT
External IDs OMIM: 123910 MGI: 109267 HomoloGene: 108184 GeneCards: GZMB Gene
EC number 3.4.21.79
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 3002 14939
Ensembl ENSG00000100453 ENSMUSG00000015437
UniProt P10144 Q3TIP3
RefSeq (mRNA) NM_004131.4 NM_013542.2
RefSeq (protein) NP_004122.2 NP_038570.1
Location (UCSC) Chr 14:
25.1 – 25.1 Mb		 Chr 14:
56.88 – 56.88 Mb
PubMed search [1] [2]

Granzyme B is a serine protease that in humans is encoded by the GZMB gene.[1] Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells.

CTL and NK cells share the remarkable ability to recognize specific infected target cells. They are thought to protect their host by inducing apoptosis of cells that bear on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.[2]

Contents

See also

References

  1. ^ Dahl CA, Bach FH, Chan W, Huebner K, Russo G, Croce CM, Herfurth T, Cairns JS (May 1990). "Isolation of a cDNA clone encoding a novel form of granzyme B from human NK cells and mapping to chromosome 14". Hum Genet 84 (5): 465–70. PMID 2323780. 
  2. ^ "Entrez Gene: GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3002. 

Further reading

External Links