GTF2H5

General transcription factor IIH, polypeptide 5

PDB rendering based on 1ydl.

Available structures
PDB	1YDL, 2JNJ

Identifiers

Symbols

GTF2H5; C6orf175; TFB5; TFIIH; TGF2H5; TTD; TTD-A; TTDA; bA120J8.2

External IDs

OMIM: 608780 MGI: 107227 HomoloGene: 45635 GeneCards: GTF2H5 Gene

Gene Ontology
Molecular function	• DNA binding
Cellular component	• nucleus
Biological process	• nucleotide-excision repair • regulation of transcription, DNA-dependent
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 6:
158.59 – 158.62 Mb

Chr 17:
6.08 – 6.09 Mb

PubMed search

[1]

[2]

General transcription factor IIH subunit 5 is a protein that in humans is encoded by the GTF2H5 gene.^[1]^[2]

Interactions

GTF2H5 has been shown to interact with GTF2H2^[1]^[3] and XPB.^[1]

References

^ ^a ^b ^c Giglia-Mari G, Coin F, Ranish JA, Hoogstraten D, Theil A, Wijgers N, Jaspers NG, Raams A, Argentini M, van der Spek PJ, Botta E, Stefanini M, Egly JM, Aebersold R, Hoeijmakers JH, Vermeulen W (Jun 2004). "A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A". Nat Genet 36 (7): 714–719. doi:10.1038/ng1387. PMID 15220921.
^ "Entrez Gene: GTF2H5 general transcription factor IIH, polypeptide 5". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=404672.
^ Vermeulen, W; Bergmann E, Auriol J, Rademakers S, Frit P, Appeldoorn E, Hoeijmakers J H, Egly J M (Nov. 2000). "Sublimiting concentration of TFIIH transcription/DNA repair factor causes TTD-A trichothiodystrophy disorder". Nat. Genet. (UNITED STATES) 26 (3): 307–313. doi:10.1038/81603. ISSN 1061-4036. PMID 11062469.

Vermeulen W, Bergmann E, Auriol J et al. (2000). "Sublimiting concentration of TFIIH transcription/DNA repair factor causes TTD-A trichothiodystrophy disorder". Nat. Genet. 26 (3): 307–313. doi:10.1038/81603. PMID 11062469.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Mungall AJ, Palmer SA, Sims SK et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–811. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Coin F, Proietti De Santis L, Nardo T et al. (2006). "p8/TTD-A as a repair-specific TFIIH subunit". Mol. Cell 21 (2): 215–226. doi:10.1016/j.molcel.2005.10.024. PMID 16427011.
Giglia-Mari G, Miquel C, Theil AF et al. (2006). "Dynamic interaction of TTDA with TFIIH is stabilized by nucleotide excision repair in living cells". PLoS Biol. 4 (6): e156. doi:10.1371/journal.pbio.0040156. PMC 1457016. PMID 16669699. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1457016.
Vitorino M, Coin F, Zlobinskaya O et al. (2007). "Solution structure and self-association properties of the p8 TFIIH subunit responsible for trichothiodystrophy". J. Mol. Biol. 368 (2): 473–480. doi:10.1016/j.jmb.2007.02.020. PMID 17350038.

PDB gallery

1ydl: Crystal Structure of the Human TFIIH, Northeast Structural Genomics Target HR2045.

2jnj: Solution structure of the p8 TFIIH subunit

GTF2H5

Interactions

References

Further reading