GRXCR1

Glutaredoxin, cysteine rich 1

Identifiers

External IDs

OMIM: 613283 HomoloGene: 42423 GeneCards: GRXCR1 Gene

Gene Ontology
Molecular function	• molecular_function • electron carrier activity • protein disulfide oxidoreductase activity
Cellular component	• cilium • stereocilium • kinocilium
Biological process	• sensory perception of sound • auditory receptor cell differentiation • cell redox homeostasis • post-embryonic organ morphogenesis • inner ear development • vestibular receptor cell development • inner ear receptor cell development • inner ear receptor stereocilium organization
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 4:
42.9 – 43.03 Mb

Chr 5:
68.42 – 68.56 Mb

PubMed search

[1]

[2]

Glutaredoxin domain-containing cysteine-rich protein 1 is a protein that in humans is encoded by the GRXCR1 gene.^[1]

This gene is one of 60 loci associated with autosomal-recessive nonsyndromic hearing impairment.^[2] This gene encodes a protein which contains GRX-like domains; these domains play a role in the S-glutathionylation of proteins and may be involved in actin organization in hair cells.^[1]

References

^ ^a ^b "Entrez Gene: glutaredoxin, cysteine rich 1". http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=389207. Retrieved 2011-08-30T19:31:40.344-07:00.
^ Schraders M, Lee K, Oostrik J, Huygen PL, Ali G, Hoefsloot LH, Veltman JA, Cremers FP, Basit S, Ansar M, Cremers CW, Kunst HP, Ahmad W, Admiraal RJ, Leal SM, Kremer H (February 2010). "Homozygosity mapping reveals mutations of GRXCR1 as a cause of autosomal-recessive nonsyndromic hearing impairment". Am. J. Hum. Genet. 86 (2): 138–47. doi:10.1016/j.ajhg.2009.12.017. PMC 2820176. PMID 20137778. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2820176.