GRIK5

Glutamate receptor, ionotropic, kainate 5
Identifiers
Symbols GRIK5; EAA2; GRIK2; KA2
External IDs OMIM: 600283 MGI: 95818 HomoloGene: 1578 GeneCards: GRIK5 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 2901 14809
Ensembl ENSG00000105737 ENSMUSG00000003378
UniProt Q16478 Q2TAX1
RefSeq (mRNA) NM_002088 NM_008168.2
RefSeq (protein) NP_002079 NP_032194.2
Location (UCSC) Chr 19:
42.5 – 42.57 Mb		 Chr 7:
25.79 – 25.86 Mb
PubMed search [1] [2]

Glutamate receptor, ionotropic kainate 5 is a protein that in humans is encoded by the GRIK5 gene.[1][2]

This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members.[2]

Contents

Interactions

GRIK5 has been shown to interact with DLG4[3][4] and GRIK2.[5][6]

See also

References

  1. ^ Szpirer C, Molne M, Antonacci R, Jenkins NA, Finelli P, Szpirer J, Riviere M, Rocchi M, Gilbert DJ, Copeland NG, et al. (Jan 1995). "The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat". Proc Natl Acad Sci U S A 91 (25): 11849–53. doi:10.1073/pnas.91.25.11849. PMC 45333. PMID 7527545. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=45333. 
  2. ^ a b "Entrez Gene: GRIK5 glutamate receptor, ionotropic, kainate 5". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2901. 
  3. ^ Mehta, S; Wu H, Garner C C, Marshall J (May. 2001). "Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97". J. Biol. Chem. (United States) 276 (19): 16092–9. doi:10.1074/jbc.M100643200. ISSN 0021-9258. PMID 11279111. 
  4. ^ Garcia, E P; Mehta S, Blair L A, Wells D G, Shang J, Fukushima T, Fallon J R, Garner C C, Marshall J (Oct. 1998). "SAP90 binds and clusters kainate receptors causing incomplete desensitization". Neuron (UNITED STATES) 21 (4): 727–39. doi:10.1016/S0896-6273(00)80590-5. ISSN 0896-6273. PMID 9808460. 
  5. ^ Wenthold, R J; Trumpy V A, Zhu W S, Petralia R S (Jan. 1994). "Biochemical and assembly properties of GluR6 and KA2, two members of the kainate receptor family, determined with subunit-specific antibodies". J. Biol. Chem. (UNITED STATES) 269 (2): 1332–9. ISSN 0021-9258. PMID 8288598. 
  6. ^ Ripellino, J A; Neve R L, Howe J R (Jan. 1998). "Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum". Neuroscience (UNITED STATES) 82 (2): 485–97. doi:10.1016/S0306-4522(97)00296-0. ISSN 0306-4522. PMID 9466455. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Cys-loop receptors
5-HT3 (A, B, C, D, E)
GABAA (α1, α2, α3, α4, α5, α6, β1, β2, β3, γ1, γ2, γ3, δ, ε, π, θ) · GABAA-ρ (ρ1, ρ2, ρ3)
α1 · α2 · α3 · α4 · β
monomers: α1 · α2 · α3 · α4 · α5 · α6 · α7 · α9 · α10 · β1 · β2 · β3 · β4 · δ · ε
pentamers: (α3)2(β4)3 · (α4)2(β2)3 · (α7)5 · (α1)2(β4)3 - Ganglion type · (α1)2β1δε - Muscle type
Zinc
Ionotropic glutamates
Ligand-gated only
AMPA (1, 2, 3, 4) · Kainate (1, 2, 3, 4, 5)
Voltage- and ligand-gated
NMDA (1, 2A, 2B, 2C, 2D, 3A, 3B, L1A, L1B)
‘Orphan’
GluD (δ1, δ2)
ATP-gated channels
P2X (1, 2, 3, 4, 5, 6, 7)
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)