GRIA1

Glutamate receptor, ionotropic, AMPA 1
Identifiers
Symbols GRIA1; GLUH1; GLUR1; GLURA; GluA1; HBGR1; MGC133252
External IDs OMIM: 138248 MGI: 95808 HomoloGene: 20226 GeneCards: GRIA1 Gene
Orthologs
Species Human Mouse
Entrez 2890 14799
Ensembl ENSG00000155511 ENSMUSG00000020524
UniProt P42261 Q5NBY0
RefSeq (mRNA) NM_000827.3 NM_008165
RefSeq (protein) NP_000818.2 NP_032191
Location (UCSC) Chr 5:
152.87 – 153.19 Mb		 Chr 11:
56.82 – 57.14 Mb
PubMed search [1] [2]

Glutamate receptor 1 is a protein that in humans is encoded by the GRIA1 gene.[1][1][2][2]

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The GRIA1 belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Each of the members (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. The receptor subunits encoded by each isoform vary in their signal transduction properties. The isoform presented here is the flop isoform. In situ hybridization experiments showed that human GRIA1 mRNA is present in granule and pyramidal cells in the hippocampal formation.[3]

Contents

Interactions

GRIA1 has been shown to interact with GRID2,[4] DLG1[5][6][7] and EPB41L2.[8]

See also

References

  1. ^ a b Puckett C, Gomez CM, Korenberg JR, Tung H, Meier TJ, Chen XN, Hood L (Oct 1991). "Molecular cloning and chromosomal localization of one of the human glutamate receptor genes". Proc Natl Acad Sci U S A 88 (17): 7557–61. doi:10.1073/pnas.88.17.7557. PMC 52340. PMID 1652753. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=52340. 
  2. ^ a b McNamara JO, Eubanks JH, McPherson JD, Wasmuth JJ, Evans GA, Heinemann SF (Jul 1992). "Chromosomal localization of human glutamate receptor genes". J Neurosci 12 (7): 2555–62. PMID 1319477. 
  3. ^ "Entrez Gene: GRIA1 glutamate receptor, ionotropic, AMPA 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2890. 
  4. ^ Kohda, Kazuhisa; Kamiya Yoshinori, Matsuda Shinji, Kato Kunio, Umemori Hisashi, Yuzaki Michisuke (Jan. 2003). "Heteromer formation of delta2 glutamate receptors with AMPA or kainate receptors". Brain Res. Mol. Brain Res. (Netherlands) 110 (1): 27–37. doi:10.1016/S0169-328X(02)00561-2. ISSN 0169-328X. PMID 12573530. 
  5. ^ Gardoni, Fabrizio; Mauceri Daniela, Fiorentini Chiara, Bellone Camilla, Missale Cristina, Cattabeni Flaminio, Di Luca Monica (Nov. 2003). "CaMKII-dependent phosphorylation regulates SAP97/NR2A interaction". J. Biol. Chem. (United States) 278 (45): 44745–52. doi:10.1074/jbc.M303576200. ISSN 0021-9258. PMID 12933808. 
  6. ^ Leonard, A S; Davare M A, Horne M C, Garner C C, Hell J W (Jul. 1998). "SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit". J. Biol. Chem. (UNITED STATES) 273 (31): 19518–24. doi:10.1074/jbc.273.31.19518. ISSN 0021-9258. PMID 9677374. 
  7. ^ Sans, N; Racca C, Petralia R S, Wang Y X, McCallum J, Wenthold R J (Oct. 2001). "Synapse-associated protein 97 selectively associates with a subset of AMPA receptors early in their biosynthetic pathway". J. Neurosci. (United States) 21 (19): 7506–16. PMID 11567040. 
  8. ^ Shen, L; Liang F, Walensky L D, Huganir R L (Nov. 2000). "Regulation of AMPA receptor GluR1 subunit surface expression by a 4. 1N-linked actin cytoskeletal association". J. Neurosci. (UNITED STATES) 20 (21): 7932–40. PMID 11050113. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Cys-loop receptors
5-HT3 (A, B, C, D, E)
GABAA (α1, α2, α3, α4, α5, α6, β1, β2, β3, γ1, γ2, γ3, δ, ε, π, θ) · GABAA-ρ (ρ1, ρ2, ρ3)
α1 · α2 · α3 · α4 · β
monomers: α1 · α2 · α3 · α4 · α5 · α6 · α7 · α9 · α10 · β1 · β2 · β3 · β4 · δ · ε
pentamers: (α3)2(β4)3 · (α4)2(β2)3 · (α7)5 · (α1)2(β4)3 - Ganglion type · (α1)2β1δε - Muscle type
Zinc
Ionotropic glutamates
Ligand-gated only
AMPA (1, 2, 3, 4) · Kainate (1, 2, 3, 4, 5)
Voltage- and ligand-gated
NMDA (1, 2A, 2B, 2C, 2D, 3A, 3B, L1A, L1B)
‘Orphan’
GluD (δ1, δ2)
ATP-gated channels
P2X (1, 2, 3, 4, 5, 6, 7)
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)