GRB14
Growth factor receptor-bound protein 14 is a protein that in humans is encoded by the GRB14 gene.[1][2]
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date.[2]
Interactions
GRB14 has been shown to interact with Epidermal growth factor receptor,[3] Fibroblast growth factor receptor 1[4] and TNKS2.[5]
References
- ^ Baker E, Sutherland GR, Sutherland RL, Daly RJ (Feb 1997). "Assignment of the human GRB14 gene to chromosome 2q22-q24 by fluorescence in situ hybridization". Genomics 36 (1): 218–220. doi:10.1006/geno.1996.0453. PMID 8812444.
- ^ a b "Entrez Gene: GRB14 growth factor receptor-bound protein 14". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2888.
- ^ Daly, R J; Sanderson G M, Janes P W, Sutherland R L (May. 1996). "Cloning and characterization of GRB14, a novel member of the GRB7 gene family". J. Biol. Chem. (UNITED STATES) 271 (21): 12502–12510. doi:10.1074/jbc.271.21.12502. ISSN 0021-9258. PMID 8647858.
- ^ Reilly, J F; Mickey G, Maher P A (Mar. 2000). "Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner". J. Biol. Chem. (UNITED STATES) 275 (11): 7771–7778. doi:10.1074/jbc.275.11.7771. ISSN 0021-9258. PMID 10713090.
- ^ Lyons, R J; Deane R, Lynch D K, Ye Z S, Sanderson G M, Eyre H J, Sutherland G R, Daly R J (May. 2001). "Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14". J. Biol. Chem. (United States) 276 (20): 17172–17180. doi:10.1074/jbc.M009756200. ISSN 0021-9258. PMID 11278563.
Further reading
- Han DC, Shen TL, Guan JL (2001). "The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions". Oncogene 20 (44): 6315–6321. doi:10.1038/sj.onc.1204775. PMID 11607834.
- Daly RJ, Sanderson GM, Janes PW, Sutherland RL (1996). "Cloning and characterization of GRB14, a novel member of the GRB7 gene family". J. Biol. Chem. 271 (21): 12502–12510. doi:10.1074/jbc.271.21.12502. PMID 8647858.
- Kasus-Jacobi A, Perdereau D, Auzan C et al. (1998). "Identification of the rat adapter Grb14 as an inhibitor of insulin actions". J. Biol. Chem. 273 (40): 26026–26035. doi:10.1074/jbc.273.40.26026. PMID 9748281.
- Jones N, Master Z, Jones J et al. (1999). "Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration". J. Biol. Chem. 274 (43): 30896–30905. doi:10.1074/jbc.274.43.30896. PMID 10521483.
- Reilly JF, Mickey G, Maher PA (2000). "Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner". J. Biol. Chem. 275 (11): 7771–7778. doi:10.1074/jbc.275.11.7771. PMID 10713090.
- Hemming R, Agatep R, Badiani K et al. (2001). "Human growth factor receptor bound 14 binds the activated insulin receptor and alters the insulin-stimulated tyrosine phosphorylation levels of multiple proteins". Biochem. Cell Biol. 79 (1): 21–32. doi:10.1139/bcb-79-1-21. PMID 11235915.
- Lyons RJ, Deane R, Lynch DK et al. (2001). "Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14". J. Biol. Chem. 276 (20): 17172–17180. doi:10.1074/jbc.M009756200. PMID 11278563.
- Béréziat V, Kasus-Jacobi A, Perdereau D et al. (2002). "Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14". J. Biol. Chem. 277 (7): 4845–4852. doi:10.1074/jbc.M106574200. PMID 11726652.
- Cariou B, Perdereau D, Cailliau K et al. (2002). "The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta". Mol. Cell. Biol. 22 (20): 6959–6970. doi:10.1128/MCB.22.20.6959-6970.2002. PMC 139806. PMID 12242277. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139806.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- King CC, Newton AC (2004). "The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1". J. Biol. Chem. 279 (36): 37518–37527. doi:10.1074/jbc.M405340200. PMID 15210700.
- Scharf PJ, Witney J, Daly R, Lyons BA (2005). "Solution structure of the human Grb14-SH2 domain and comparison with the structures of the human Grb7-SH2/erbB2 peptide complex and human Grb10-SH2 domain". Protein Sci. 13 (9): 2541–2546. doi:10.1110/ps.04884704. PMC 2280013. PMID 15322292. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2280013.
- Kairouz R, Parmar J, Lyons RJ et al. (2005). "Hormonal regulation of the Grb14 signal modulator and its role in cell cycle progression of MCF-7 human breast cancer cells". J. Cell. Physiol. 203 (1): 85–93. doi:10.1002/jcp.20199. PMID 15372466.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Depetris RS, Hu J, Gimpelevich I et al. (2006). "Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14". Mol. Cell 20 (2): 325–333. doi:10.1016/j.molcel.2005.09.001. PMID 16246733.
- Park JJ, Berggren JR, Hulver MW et al. (2006). "GRB14, GPD1, and GDF8 as potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle". Physiol. Genomics 27 (2): 114–121. doi:10.1152/physiolgenomics.00045.2006. PMID 16849634.
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PDB gallery
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2aug: Crystal structure of the Grb14 SH2 domain
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2auh: Crystal structure of the Grb14 BPS region in complex with the insulin receptor tyrosine kinase
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