GPVI
Glycoprotein VI (platelet) also known as GPVI is a glycoprotein receptor for collagen which is expressed in platelets. In humans, glycoprotein VI is encoded by the GPVI gene.[1]
Function
Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke.[2][3]
Interactions
GPVI has been shown to interact with LYN.[4]
See also
References
- ^ Ezumi Y, Uchiyama T, Takayama H (October 2000). "Molecular cloning, genomic structure, chromosomal localization, and alternative splice forms of the platelet collagen receptor glycoprotein VI". Biochem. Biophys. Res. Commun. 277 (1): 27–36. doi:10.1006/bbrc.2000.3624. PMID 11027634.
- ^ "Entrez Gene: GP6 glycoprotein VI (platelet)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51206.
- ^ Jandrot-Perrus M, Busfield S, Lagrue AH, Xiong X, Debili N, Chickering T, Le Couedic JP, Goodearl A, Dussault B, Fraser C, Vainchenker W, Villeval JL (September 2000). "Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily". Blood 96 (5): 1798–807. PMID 10961879. http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=10961879.
- ^ Suzuki-Inoue, Katsue; Tulasne David, Shen Yang, Bori-Sanz Teresa, Inoue Osamu, Jung Stephanie M, Moroi Masaaki, Andrews Robert K, Berndt Michael C, Watson Steve P (Jun. 2002). "Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling". J. Biol. Chem. (United States) 277 (24): 21561–6. doi:10.1074/jbc.M201012200. ISSN 0021-9258. PMID 11943772.
Further reading
- Nieswandt B, Watson SP (2003). "Platelet-collagen interaction: is GPVI the central receptor?". Blood 102 (2): 449–61. doi:10.1182/blood-2002-12-3882. PMID 12649139.
- Watson SP, Auger JM, McCarty OJ, Pearce AC (2005). "GPVI and integrin alphaIIb beta3 signaling in platelets.". J. Thromb. Haemost. 3 (8): 1752–62. doi:10.1111/j.1538-7836.2005.01429.x. PMID 16102042.
- Huang MM, Bolen JB, Barnwell JW et al. (1991). "Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets". Proc. Natl. Acad. Sci. U.S.A. 88 (17): 7844–8. doi:10.1073/pnas.88.17.7844. PMC 52400. PMID 1715582. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=52400.
- Moroi M, Jung SM, Okuma M, Shinmyozu K (1989). "A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion". J. Clin. Invest. 84 (5): 1440–5. doi:10.1172/JCI114318. PMC 304007. PMID 2808700. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=304007.
- Polgár J, Clemetson JM, Kehrel BE et al. (1997). "Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor". J. Biol. Chem. 272 (21): 13576–83. doi:10.1074/jbc.272.21.13576. PMID 9153205.
- Gibbins JM, Okuma M, Farndale R et al. (1997). "Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain". FEBS Lett. 413 (2): 255–9. doi:10.1016/S0014-5793(97)00926-5. PMID 9280292.
- Tsuji M, Ezumi Y, Arai M, Takayama H (1997). "A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets". J. Biol. Chem. 272 (38): 23528–31. doi:10.1074/jbc.272.38.23528. PMID 9295288.
- Clemetson JM, Polgar J, Magnenat E et al. (1999). "The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer receptors". J. Biol. Chem. 274 (41): 29019–24. doi:10.1074/jbc.274.41.29019. PMID 10506151.
- Miura Y, Ohnuma M, Jung SM, Moroi M (2000). "Cloning and expression of the platelet-specific collagen receptor glycoprotein VI". Thromb. Res. 98 (4): 301–9. doi:10.1016/S0049-3848(00)00182-1. PMID 10822077.
- Nieswandt B, Bergmeier W, Schulte V et al. (2000). "Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRgamma chain". J. Biol. Chem. 275 (31): 23998–4002. doi:10.1074/jbc.M003803200. PMID 10825177.
- Jandrot-Perrus M, Busfield S, Lagrue AH et al. (2000). "Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily". Blood 96 (5): 1798–807. PMID 10961879.
- Ezumi Y, Uchiyama T, Takayama H (2000). "Molecular cloning, genomic structure, chromosomal localization, and alternative splice forms of the platelet collagen receptor glycoprotein VI". Biochem. Biophys. Res. Commun. 277 (1): 27–36. doi:10.1006/bbrc.2000.3624. PMID 11027634.
- Barry FA, Gibbins JM (2002). "Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI". J. Biol. Chem. 277 (15): 12874–8. doi:10.1074/jbc.M200482200. PMID 11825911.
- Suzuki-Inoue K, Tulasne D, Shen Y et al. (2002). "Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling". J. Biol. Chem. 277 (24): 21561–6. doi:10.1074/jbc.M201012200. PMID 11943772.
- Quinton TM, Ozdener F, Dangelmaier C et al. (2002). "Glycoprotein VI-mediated platelet fibrinogen receptor activation occurs through calcium-sensitive and PKC-sensitive pathways without a requirement for secreted ADP". Blood 99 (9): 3228–34. doi:10.1182/blood.V99.9.3228. PMID 11964287.
- Saving KL, Mankin PE, Gorman MJ (2002). "Differences in adhesion receptor expression between immature and older platelets and red blood cells of neonates and adults". J. Pediatr. Hematol. Oncol. 24 (2): 120–4. doi:10.1097/00043426-200202000-00012. PMID 11990697.
- Andrews RK, Suzuki-Inoue K, Shen Y et al. (2002). "Interaction of calmodulin with the cytoplasmic domain of platelet glycoprotein VI". Blood 99 (11): 4219–21. doi:10.1182/blood-2001-11-0008. PMID 12010829.
- Wonerow P, Obergfell A, Wilde JI et al. (2002). "Differential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin-mediated phospholipase Cgamma2 regulation in platelets". Biochem. J. 364 (Pt 3): 755–65. doi:10.1042/BJ20020128. PMC 1222625. PMID 12049640. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1222625.
- Miura Y, Takahashi T, Jung SM, Moroi M (2003). "Analysis of the interaction of platelet collagen receptor glycoprotein VI (GPVI) with collagen. A dimeric form of GPVI, but not the monomeric form, shows affinity to fibrous collagen". J. Biol. Chem. 277 (48): 46197–204. doi:10.1074/jbc.M204029200. PMID 12356768.
- Holmes ML, Bartle N, Eisbacher M, Chong BH (2003). "Cloning and analysis of the thrombopoietin-induced megakaryocyte-specific glycoprotein VI promoter and its regulation by GATA-1, Fli-1, and Sp1". J. Biol. Chem. 277 (50): 48333–41. doi:10.1074/jbc.M206127200. PMID 12359731.
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PDB gallery
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2gi7: Crystal structure of human platelet Glycoprotein VI (GPVI)
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External links