GPSM2
G-protein-signaling modulator 2 is a protein that in humans is encoded by the GPSM2 gene.[1][2][3]
Heterotrimeric G proteins transduce extracellular signals received by cell surface receptors into integrated cellular responses. GPSM2 belongs to a group of proteins that modulate activation of G proteins (Blumer et al., 2002).[supplied by OMIM][3]
Interactions
GPSM2 has been shown to interact with Nuclear mitotic apparatus protein 1[4] and GNAI2.[2][5]
References
- ^ Blumer JB, Chandler LJ, Lanier SM (Apr 2002). "Expression analysis and subcellular distribution of the two G-protein regulators AGS3 and LGN indicate distinct functionality. Localization of LGN to the midbody during cytokinesis". J Biol Chem 277 (18): 15897–903. doi:10.1074/jbc.M112185200. PMID 11832491.
- ^ a b Mochizuki N, Cho G, Wen B, Insel PA (Jan 1997). "Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with G alpha i2". Gene 181 (1–2): 39–43. doi:10.1016/S0378-1119(96)00456-8. PMID 8973305.
- ^ a b "Entrez Gene: GPSM2 G-protein signalling modulator 2 (AGS3-like, C. elegans)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29899.
- ^ Du, Q; Stukenberg P T, Macara I G (Dec. 2001). "A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization". Nat. Cell Biol. (England) 3 (12): 1069–75. doi:10.1038/ncb1201-1069. ISSN 1465-7392. PMID 11781568.
- ^ Marty, Caroline; Browning Darren D, Ye Richard D (Jun. 2003). "Identification of Tetratricopeptide Repeat 1 as an Adaptor Protein That Interacts with Heterotrimeric G Proteins and the Small GTPase Ras". Mol. Cell. Biol. (United States) 23 (11): 3847–58. doi:10.1128/MCB.23.11.3847-3858.2003. ISSN 0270-7306. PMC 155206. PMID 12748287. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=155206.
Further reading
- Du Q, Stukenberg PT, Macara IG (2002). "A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization". Nat. Cell Biol. 3 (12): 1069–75. doi:10.1038/ncb1201-1069. PMID 11781568.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Marty C, Browning DD, Ye RD (2003). "Identification of Tetratricopeptide Repeat 1 as an Adaptor Protein That Interacts with Heterotrimeric G Proteins and the Small GTPase Ras". Mol. Cell. Biol. 23 (11): 3847–58. doi:10.1128/MCB.23.11.3847-3858.2003. PMC 155206. PMID 12748287. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=155206.
- Kaushik R, Yu F, Chia W et al. (2004). "Subcellular Localization of LGN During Mitosis: Evidence for Its Cortical Localization in Mitotic Cell Culture Systems and Its Requirement for Normal Cell Cycle Progression". Mol. Biol. Cell 14 (8): 3144–55. doi:10.1091/mbc.E03-04-0212. PMC 181556. PMID 12925752. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=181556.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Du Q, Macara IG (2004). "Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins". Cell 119 (4): 503–16. doi:10.1016/j.cell.2004.10.028. PMID 15537540.
- Yasumi M, Sakisaka T, Hoshino T et al. (2005). "Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell division". J. Biol. Chem. 280 (8): 6761–5. doi:10.1074/jbc.C400440200. PMID 15632202.
- Yang J, Kamide K, Kokubo Y et al. (2005). "Genetic variations of regulator of G-protein signaling 2 in hypertensive patients and in the general population". J. Hypertens. 23 (8): 1497–505. doi:10.1097/01.hjh.0000174606.41651.ae. PMID 16003176.
- Izaki T, Kamakura S, Kohjima M, Sumimoto H (2006). "Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3". Biochem. Biophys. Res. Commun. 341 (4): 1001–6. doi:10.1016/j.bbrc.2006.01.050. PMID 16458856.