GOLGA2
Golgin subfamily A member 2 is a protein that in humans is encoded by the GOLGA2 gene.[1]
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. The golgins are a family of proteins, of which the protein encoded by this gene is a member, that are localized to the Golgi. This encoded protein has been postulated to play roles in the stacking of Golgi cisternae and in vesicular transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined.[2]
Interactions
GOLGA2 has been shown to interact with RAB2A,[3][4] GORASP2,[5][6][4] RAB1A,[7][8][4] RAB1B[9] and GORASP1.[6][10][4][5]
References
- ^ Fritzler MJ, Hamel JC, Ochs RL, Chan EK (Jul 1993). "Molecular characterization of two human autoantigens: unique cDNAs encoding 95- and 160-kD proteins of a putative family in the Golgi complex". J Exp Med 178 (1): 49–62. doi:10.1084/jem.178.1.49. PMC 2191081. PMID 8315394. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2191081.
- ^ "Entrez Gene: GOLGA2 golgi autoantigen, golgin subfamily a, 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2801.
- ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- ^ a b c d Short, B; Preisinger C, Körner R, Kopajtich R, Byron O, Barr F A (Dec. 2001). "A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic". J. Cell Biol. (United States) 155 (6): 877–83. doi:10.1083/jcb.200108079. ISSN 0021-9525. PMC 2150909. PMID 11739401. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2150909.
- ^ a b Shorter, J; Watson R, Giannakou M E, Clarke M, Warren G, Barr F A (Sep. 1999). "GRASP55, a second mammalian GRASP protein involved in the stacking of Golgi cisternae in a cell-free system". EMBO J. (ENGLAND) 18 (18): 4949–60. doi:10.1093/emboj/18.18.4949. ISSN 0261-4189. PMC 1171566. PMID 10487747. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171566.
- ^ a b Barr, F A; Preisinger C, Kopajtich R, Körner R (Dec. 2001). "Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus". J. Cell Biol. (United States) 155 (6): 885–91. doi:10.1083/jcb.200108102. ISSN 0021-9525. PMC 2150891. PMID 11739402. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2150891.
- ^ Weide, Thomas; Teuber Julia, Bayer Michael, Barnekow Angelika (Jun. 2003). "MICAL-1 isoforms, novel rab1 interacting proteins". Biochem. Biophys. Res. Commun. (United States) 306 (1): 79–86. doi:10.1016/S0006-291X(03)00918-5. ISSN 0006-291X. PMID 12788069.
- ^ Valsdottir, R; Hashimoto H, Ashman K, Koda T, Storrie B, Nilsson T (Nov. 2001). "Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER". FEBS Lett. (Netherlands) 508 (2): 201–9. doi:10.1016/S0014-5793(01)02993-3. ISSN 0014-5793. PMID 11718716.
- ^ Weide, T; Bayer M, Köster M, Siebrasse J P, Peters R, Barnekow A (Apr. 2001). "The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b". EMBO Rep. (England) 2 (4): 336–41. doi:10.1093/embo-reports/kve065. ISSN 1469-221X. PMC 1083862. PMID 11306556. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1083862.
- ^ Marra, P; Maffucci T, Daniele T, Tullio G D, Ikehara Y, Chan E K, Luini A, Beznoussenko G, Mironov A, De Matteis M A (Dec. 2001). "The GM130 and GRASP65 Golgi proteins cycle through and define a subdomain of the intermediate compartment". Nat. Cell Biol. (England) 3 (12): 1101–13. doi:10.1038/ncb1201-1101. ISSN 1465-7392. PMID 11781572.
Further reading
- Nakamura N, Rabouille C, Watson R et al. (1996). "Characterization of a cis-Golgi matrix protein, GM130". J. Cell Biol. 131 (6 Pt 2): 1715–26. doi:10.1083/jcb.131.6.1715. PMC 2120691. PMID 8557739. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2120691.
- Nakamura N, Lowe M, Levine TP et al. (1997). "The vesicle docking protein p115 binds GM130, a cis-Golgi matrix protein, in a mitotically regulated manner". Cell 89 (3): 445–55. doi:10.1016/S0092-8674(00)80225-1. PMID 9150144.
- Barr FA, Puype M, Vandekerckhove J, Warren G (1997). "GRASP65, a protein involved in the stacking of Golgi cisternae". Cell 91 (2): 253–62. doi:10.1016/S0092-8674(00)80407-9. PMID 9346242.
- Sohda M, Misumi Y, Yano A et al. (1998). "Phosphorylation of the vesicle docking protein p115 regulates its association with the Golgi membrane". J. Biol. Chem. 273 (9): 5385–8. doi:10.1074/jbc.273.9.5385. PMID 9478999.
- Barr FA, Nakamura N, Warren G (1998). "Mapping the interaction between GRASP65 and GM130, components of a protein complex involved in the stacking of Golgi cisternae". EMBO J. 17 (12): 3258–68. doi:10.1093/emboj/17.12.3258. PMC 1170664. PMID 9628863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170664.
- Lowe M, Rabouille C, Nakamura N et al. (1998). "Cdc2 kinase directly phosphorylates the cis-Golgi matrix protein GM130 and is required for Golgi fragmentation in mitosis". Cell 94 (6): 783–93. doi:10.1016/S0092-8674(00)81737-7. PMID 9753325.
- Barr FA (1999). "A novel Rab6-interacting domain defines a family of Golgi-targeted coiled-coil proteins". Curr. Biol. 9 (7): 381–4. doi:10.1016/S0960-9822(99)80167-5. PMID 10209123.
- Shorter J, Watson R, Giannakou ME et al. (1999). "GRASP55, a second mammalian GRASP protein involved in the stacking of Golgi cisternae in a cell-free system". EMBO J. 18 (18): 4949–60. doi:10.1093/emboj/18.18.4949. PMC 1171566. PMID 10487747. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171566.
- Bouchireb N, Clark MS (1999). "Human golgin-95 gene (GOLGA2). Map position 9q32-34.1". Chromosome Res. 7 (6): 501. doi:10.1023/A:1009210232273. PMID 10560974.
- Linstedt AD, Jesch SA, Mehta A et al. (2000). "Binding relationships of membrane tethering components. The giantin N terminus and the GM130 N terminus compete for binding to the p115 C terminus". J. Biol. Chem. 275 (14): 10196–201. doi:10.1074/jbc.275.14.10196. PMID 10744704.
- Lowe M, Gonatas NK, Warren G (2000). "The Mitotic Phosphorylation Cycle of the Cis-Golgi Matrix Protein Gm130". J. Cell Biol. 149 (2): 341–56. doi:10.1083/jcb.149.2.341. PMC 2175168. PMID 10769027. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2175168.
- Alvarez C, Garcia-Mata R, Hauri HP, Sztul E (2001). "The p115-interactive proteins GM130 and giantin participate in endoplasmic reticulum-Golgi traffic". J. Biol. Chem. 276 (4): 2693–700. doi:10.1074/jbc.M007957200. PMID 11035033.
- Moyer BD, Allan BB, Balch WE (2001). "Rab1 interaction with a GM130 effector complex regulates COPII vesicle cis--Golgi tethering". Traffic 2 (4): 268–76. doi:10.1034/j.1600-0854.2001.1o007.x. PMID 11285137.
- Weide T, Bayer M, Köster M et al. (2001). "The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b". EMBO Rep. 2 (4): 336–41. doi:10.1093/embo-reports/kve065. PMC 1083862. PMID 11306556. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1083862.
- Puthenveedu MA, Linstedt AD (2001). "Evidence that Golgi structure depends on a p115 activity that is independent of the vesicle tether components giantin and GM130". J. Cell Biol. 155 (2): 227–38. doi:10.1083/jcb.200105005. PMC 2198842. PMID 11591729. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2198842.
- Miles S, McManus H, Forsten KE, Storrie B (2001). "Evidence that the entire Golgi apparatus cycles in interphase HeLa cells: sensitivity of Golgi matrix proteins to an ER exit block". J. Cell Biol. 155 (4): 543–55. doi:10.1083/jcb.200103104. PMC 2198853. PMID 11696556. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2198853.
- Majoul I, Straub M, Hell SW et al. (2001). "KDEL-cargo regulates interactions between proteins involved in COPI vesicle traffic: measurements in living cells using FRET". Dev. Cell 1 (1): 139–53. doi:10.1016/S1534-5807(01)00004-1. PMID 11703931.
- Valsdottir R, Hashimoto H, Ashman K et al. (2001). "Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER". FEBS Lett. 508 (2): 201–9. doi:10.1016/S0014-5793(01)02993-3. PMID 11718716.
- Short B, Preisinger C, Körner R et al. (2002). "A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic". J. Cell Biol. 155 (6): 877–83. doi:10.1083/jcb.200108079. PMC 2150909. PMID 11739401. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2150909.