GNAO1

Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O

Identifiers

GNAO1; DKFZp686O0962; G-ALPHA-o; GNAO

External IDs

OMIM: 139311 MGI: 95775 HomoloGene: 39203 GeneCards: GNAO1 Gene

Gene Ontology
Molecular function	• nucleotide binding • GTPase activity • GTPase activity • signal transducer activity • GTP binding • guanyl nucleotide binding • G-protein beta/gamma-subunit complex binding • metabotropic serotonin receptor binding • mu-type opioid receptor binding
Cellular component	• intracellular • heterotrimeric G-protein complex • plasma membrane • plasma membrane • synaptosome • extrinsic to internal side of plasma membrane
Biological process	• GTP catabolic process • GTP catabolic process • muscle contraction • G-protein signaling, coupled to cAMP nucleotide second messenger • dopamine receptor signaling pathway • aging • locomotory behavior • regulation of heart contraction • cellular process • response to organic nitrogen • response to organic cyclic compound • forebrain development • neuron projection development • response to cytokine stimulus • response to drug • response to hydrogen peroxide • response to morphine • positive regulation of GTPase activity • negative regulation of calcium ion transport
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 16:
56.23 – 56.39 Mb

Chr 8:
96.33 – 96.49 Mb

PubMed search

[1]

[2]

Guanine nucleotide-binding protein G(o) subunit alpha is a protein that in humans is encoded by the GNAO1 gene.^[1]^[2]^[3]

Interactions

GNAO1 has been shown to interact with RGS20,^[4] RGS19,^[5]^[6] RIC8A^[7] and RGS5.^[8]^[9]

References

^ Murtagh JJ Jr, Eddy R, Shows TB, Moss J, Vaughan M (Mar 1991). "Different forms of Go alpha mRNA arise by alternative splicing of transcripts from a single gene on human chromosome 16". Mol Cell Biol 11 (2): 1146–55. PMC 359797. PMID 1899283. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=359797.
^ Kinoshita M, Nukada T, Asano T, Mori Y, Akaike A, Satoh M, Kaneko S (Jul 2001). "Binding of G alpha(o) N terminus is responsible for the voltage-resistant inhibition of alpha(1A) (P/Q-type, Ca(v)2.1) Ca(2+) channels". J Biol Chem 276 (31): 28731–8. doi:10.1074/jbc.M104806200. PMID 11395521.
^ "Entrez Gene: GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2775.
^ Pagano, Mario; Jordan J Dedrick, Neves Susana R, Nguyen Tracy, Iyengar Ravi (Jun. 2008). "Galphao/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways". Cell. Signal. (England) 20 (6): 1190–7. doi:10.1016/j.cellsig.2008.02.008. ISSN 0898-6568. PMID 18407463.
^ De Vries, L; Elenko E, Hubler L, Jones T L, Farquhar M G (Dec. 1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (26): 15203–8. doi:10.1073/pnas.93.26.15203. ISSN 0027-8424. PMC 26381. PMID 8986788. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=26381.
^ Woulfe, D S; Stadel J M (Jun. 1999). "Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP". J. Biol. Chem. (UNITED STATES) 274 (25): 17718–24. doi:10.1074/jbc.274.25.17718. ISSN 0021-9258. PMID 10364213.
^ Tall, Gregory G; Krumins Andrejs M, Gilman Alfred G (Mar. 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". J. Biol. Chem. (United States) 278 (10): 8356–62. doi:10.1074/jbc.M211862200. ISSN 0021-9258. PMID 12509430.
^ Chen, C; Zheng B, Han J, Lin S C (Mar. 1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast". J. Biol. Chem. (UNITED STATES) 272 (13): 8679–85. doi:10.1074/jbc.272.13.8679. ISSN 0021-9258. PMID 9079700.
^ Zhou, J; Moroi K, Nishiyama M, Usui H, Seki N, Ishida J, Fukamizu A, Kimura S (Feb. 2001). "Characterization of RGS5 in regulation of G protein-coupled receptor signaling". Life Sci. (England) 68 (13): 1457–69. doi:10.1016/S0024-3205(01)00939-0. ISSN 0024-3205. PMID 11253162.

Raymond JR, Mukhin YV, Gelasco A, et al. (2002). "Multiplicity of mechanisms of serotonin receptor signal transduction.". Pharmacol. Ther. 92 (2-3): 179–212. doi:10.1016/S0163-7258(01)00169-3. PMID 11916537.
Coupry I, Duzic E, Lanier SM (1992). "Factors determining the specificity of signal transduction by guanine nucleotide-binding protein-coupled receptors. II. Preferential coupling of the alpha 2C-adrenergic receptor to the guanine nucleotide-binding protein, Go.". J. Biol. Chem. 267 (14): 9852–7. PMID 1349607.
Denker BM, Neer EJ, Schmidt CJ (1992). "Mutagenesis of the amino terminus of the alpha subunit of the G protein Go. In vitro characterization of alpha o beta gamma interactions.". J. Biol. Chem. 267 (9): 6272–7. PMID 1556134.
Yi F, Denker BM, Neer EJ (1991). "Structural and functional studies of cross-linked Go protein subunits.". J. Biol. Chem. 266 (6): 3900–6. PMID 1899868.
Tsukamoto T, Toyama R, Itoh H, et al. (1991). "Structure of the human gene and two rat cDNAs encoding the alpha chain of GTP-binding regulatory protein Go: two different mRNAs are generated by alternative splicing.". Proc. Natl. Acad. Sci. U.S.A. 88 (8): 2974–8. doi:10.1073/pnas.88.8.2974. PMC 51366. PMID 1901650. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=51366.
Gabrion J, Brabet P, Nguyen Than Dao B, et al. (1990). "Ultrastructural localization of the GTP-binding protein Go in neurons.". Cell. Signal. 1 (1): 107–23. doi:10.1016/0898-6568(89)90025-9. PMID 2518353.
Lavu S, Clark J, Swarup R, et al. (1988). "Molecular cloning and DNA sequence analysis of the human guanine nucleotide-binding protein Go alpha.". Biochem. Biophys. Res. Commun. 150 (2): 811–5. doi:10.1016/0006-291X(88)90463-9. PMID 3124840.
Zumbihl R, Breuiller-Fouché M, Carrette J, et al. (1995). "Up-regulation in late pregnancy of both Go1 alpha and Go2 alpha isoforms in human myometrium.". Eur. J. Pharmacol. 288 (1): 9–15. doi:10.1016/0922-4106(94)90004-3. PMID 7705473.
Grassie MA, Milligan G (1995). "Analysis of the relative interactions between the alpha 2C10 adrenoceptor and the guanine-nucleotide-binding proteins G(o)1 alpha and Gi 2 alpha following co-expression of these polypeptides in rat 1 fibroblasts.". Biochem. J. 306 ( Pt 2): 525–30. PMC 1136549. PMID 7887906. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1136549.
Wu HC, Lin CT (1994). "Association of heterotrimeric GTP binding regulatory protein (Go) with mitosis.". Lab. Invest. 71 (2): 175–81. PMID 8078296.
Nitta K, Uchida K, Kawashima A, et al. (1994). "Identification of GTP-binding proteins in human glomeruli.". Nippon Jinzo Gakkai shi 36 (1): 9–12. PMID 8107314.
Georgoussi Z, Carr C, Milligan G (1993). "Direct measurements of in situ interactions of rat brain opioid receptors with the guanine nucleotide-binding protein Go.". Mol. Pharmacol. 44 (1): 62–9. PMID 8393523.
Laugwitz KL, Allgeier A, Offermanns S, et al. (1996). "The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families.". Proc. Natl. Acad. Sci. U.S.A. 93 (1): 116–20. doi:10.1073/pnas.93.1.116. PMC 40189. PMID 8552586. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=40189.
Kawano N, Ito T, Kitamura H, et al. (1997). "Immunoexpression of the alpha subunit of a guanine nucleotide-binding protein (Go) in pulmonary neuroendocrine cells and neoplasms.". Pathol. Int. 46 (6): 393–8. doi:10.1111/j.1440-1827.1996.tb03629.x. PMID 8869990.
De Vries L, Elenko E, Hubler L, et al. (1997). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits.". Proc. Natl. Acad. Sci. U.S.A. 93 (26): 15203–8. doi:10.1073/pnas.93.26.15203. PMC 26381. PMID 8986788. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=26381.
Valenzuela D, Han X, Mende U, et al. (1997). "G alpha(o) is necessary for muscarinic regulation of Ca2+ channels in mouse heart.". Proc. Natl. Acad. Sci. U.S.A. 94 (5): 1727–32. doi:10.1073/pnas.94.5.1727. PMC 19984. PMID 9050846. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=19984.
Chen C, Zheng B, Han J, Lin SC (1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast.". J. Biol. Chem. 272 (13): 8679–85. doi:10.1074/jbc.272.13.8679. PMID 9079700.
Natochin M, Lipkin VM, Artemyev NO (1997). "Interaction of human retinal RGS with G-protein alpha-subunits.". FEBS Lett. 411 (2-3): 179–82. doi:10.1016/S0014-5793(97)00687-X. PMID 9271201.
Busconi L, Denker BM (1998). "Analysis of the N-terminal binding domain of Go alpha.". Biochem. J. 328 ( Pt 1): 23–31. PMC 1218882. PMID 9359829. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1218882.

GNAO1

Interactions

References

Further reading