GNA13
Guanine nucleotide-binding protein subunit alpha-13 is a protein that in humans is encoded by the GNA13 gene.[1][2]
Interactions
GNA13 has been shown to interact with ARHGEF1,[3][4][5] AKAP3,[6] RIC8A,[7] Radixin[8] and ARHGEF12.[9][10]
See also
References
- ^ Kabouridis PS, Waters ST, Escobar S, Stanners J, Tsoukas CD (Jul 1995). "Expression of GTP-binding protein alpha subunits in human thymocytes". Mol Cell Biochem 144 (1): 45–51. doi:10.1007/BF00926739. PMID 7791744.
- ^ "Entrez Gene: GNA13 guanine nucleotide binding protein (G protein), alpha 13". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10672.
- ^ Johnson EN, Seasholtz TM, Waheed AA et al. (December 2003). "RGS16 inhibits signalling through the G alpha 13-Rho axis". Nat. Cell Biol. 5 (12): 1095–103. doi:10.1038/ncb1065. PMID 14634662.
- ^ Bhattacharyya, Raja; Wedegaertner Philip B (Apr. 2003). "Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitment". FEBS Lett. (Netherlands) 540 (1–3): 211–6. doi:10.1016/S0014-5793(03)00267-9. ISSN 0014-5793. PMID 12681510.
- ^ Hart, M J; Jiang X, Kozasa T, Roscoe W, Singer W D, Gilman A G, Sternweis P C, Bollag G (Jun. 1998). "Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13". Science (UNITED STATES) 280 (5372): 2112–4. doi:10.1126/science.280.5372.2112. ISSN 0036-8075. PMID 9641916.
- ^ Niu, J; Vaiskunaite R, Suzuki N, Kozasa T, Carr D W, Dulin N, Voyno-Yasenetskaya T A (Oct. 2001). "Interaction of heterotrimeric G13 protein with an A-kinase-anchoring protein 110 (AKAP110) mediates cAMP-independent PKA activation". Curr. Biol. (England) 11 (21): 1686–90. doi:10.1016/S0960-9822(01)00530-9. ISSN 0960-9822. PMID 11696326.
- ^ Tall, Gregory G; Krumins Andrejs M, Gilman Alfred G (Mar. 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". J. Biol. Chem. (United States) 278 (10): 8356–62. doi:10.1074/jbc.M211862200. ISSN 0021-9258. PMID 12509430.
- ^ Vaiskunaite, R; Adarichev V, Furthmayr H, Kozasa T, Gudkov A, Voyno-Yasenetskaya T A (Aug. 2000). "Conformational activation of radixin by G13 protein alpha subunit". J. Biol. Chem. (UNITED STATES) 275 (34): 26206–12. doi:10.1074/jbc.M001863200. ISSN 0021-9258. PMID 10816569.
- ^ Fukuhara, S; Chikumi H, Gutkind J S (Nov. 2000). "Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho". FEBS Lett. (NETHERLANDS) 485 (2–3): 183–8. doi:10.1016/S0014-5793(00)02224-9. ISSN 0014-5793. PMID 11094164.
- ^ Suzuki, Nobuchika; Nakamura Susumu, Mano Hiroyuki, Kozasa Tohru (Jan. 2003). "Gα12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (2): 733–8. doi:10.1073/pnas.0234057100. ISSN 0027-8424. PMC 141065. PMID 12515866. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=141065.
Further reading
- Ruppel KM, Willison D, Kataoka H, Wang A, Zheng YW, Cornelissen I, Liya Yin, Xu SM, and Coughlin SR (2005). "Essential role for Gα13 in endothelial cells during embryonic development". Proc. Natl. Acad. Sci. U.S.A. 102 (22): 8281–8286. doi:10.1073/pnas.0503326102. PMC 1149452. PMID 15919816. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1149452.
- Downes GB, Gautam N (2000). "The G protein subunit gene families". Genomics 62 (3): 544–52. doi:10.1006/geno.1999.5992. PMID 10644457.
- Offermanns S, Laugwitz KL, Spicher K, Schultz G (1994). "G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets". Proc. Natl. Acad. Sci. U.S.A. 91 (2): 504–8. doi:10.1073/pnas.91.2.504. PMC 42977. PMID 8290554. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=42977.
- Laugwitz KL, Allgeier A, Offermanns S et al. (1996). "The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families". Proc. Natl. Acad. Sci. U.S.A. 93 (1): 116–20. doi:10.1073/pnas.93.1.116. PMC 40189. PMID 8552586. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=40189.
- Offermanns S, Hu YH, Simon MI (1996). "Galpha12 and galpha13 are phosphorylated during platelet activation". J. Biol. Chem. 271 (42): 26044–8. doi:10.1074/jbc.271.42.26044. PMID 8824244.
- Offermanns S, Mancino V, Revel JP, Simon MI (1997). "Vascular system defects and impaired cell chemokinesis as a result of Galpha13 deficiency". Science 275 (5299): 533–6. doi:10.1126/science.275.5299.533. PMID 8999798.
- Macrez-Leprêtre N, Kalkbrenner F, Morel JL et al. (1997). "G protein heterotrimer Galpha13beta1gamma3 couples the angiotensin AT1A receptor to increases in cytoplasmic Ca2+ in rat portal vein myocytes". J. Biol. Chem. 272 (15): 10095–102. doi:10.1074/jbc.272.15.10095. PMID 9092554.
- Hart MJ, Jiang X, Kozasa T et al. (1998). "Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13". Science 280 (5372): 2112–4. doi:10.1126/science.280.5372.2112. PMID 9641916.
- Fukuhara S, Murga C, Zohar M et al. (1999). "A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho". J. Biol. Chem. 274 (9): 5868–79. doi:10.1074/jbc.274.9.5868. PMID 10026210.
- Becker KP, Garnovskaya M, Gettys T, Halushka PV (1999). "Coupling of thromboxane A2 receptor isoforms to Galpha13: effects on ligand binding and signalling". Biochim. Biophys. Acta 1450 (3): 288–96. doi:10.1016/S0167-4889(99)00068-3. PMID 10395940.
- Windh RT, Lee MJ, Hla T et al. (1999). "Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins". J. Biol. Chem. 274 (39): 27351–8. doi:10.1074/jbc.274.39.27351. PMID 10488065.
- Brydon L, Roka F, Petit L et al. (2000). "Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins". Mol. Endocrinol. 13 (12): 2025–38. doi:10.1210/me.13.12.2025. PMID 10598579.
- Bhattacharyya R, Wedegaertner PB (2000). "Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding". J. Biol. Chem. 275 (20): 14992–9. doi:10.1074/jbc.M000415200. PMID 10747909.
- Vaiskunaite R, Adarichev V, Furthmayr H et al. (2000). "Conformational activation of radixin by G13 protein alpha subunit". J. Biol. Chem. 275 (34): 26206–12. doi:10.1074/jbc.M001863200. PMID 10816569.
- Shi CS, Sinnarajah S, Cho H et al. (2000). "G13alpha-mediated PYK2 activation. PYK2 is a mediator of G13alpha -induced serum response element-dependent transcription". J. Biol. Chem. 275 (32): 24470–6. doi:10.1074/jbc.M908449199. PMID 10821841.
- Ponimaskin E, Behn H, Adarichev V et al. (2000). "Acylation of Galpha(13) is important for its interaction with thrombin receptor, transforming activity and actin stress fiber formation". FEBS Lett. 478 (1–2): 173–7. doi:10.1016/S0014-5793(00)01845-7. PMID 10922491.
- Jin S, Exton JH (2000). "Activation of RhoA by association of Galpha(13) with Dbl". Biochem. Biophys. Res. Commun. 277 (3): 718–21. doi:10.1006/bbrc.2000.3744. PMID 11062019.
- Fukuhara S, Chikumi H, Gutkind JS (2000). "Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho". FEBS Lett. 485 (2–3): 183–8. doi:10.1016/S0014-5793(00)02224-9. PMID 11094164.
- Meigs TE, Fields TA, McKee DD, Casey PJ (2001). "Interaction of Gα12 and Gα13 with the cytoplasmic domain of cadherin provides a mechanism for β-catenin release". Proc. Natl. Acad. Sci. U.S.A. 98 (2): 519–24. doi:10.1073/pnas.021350998. PMC 14619. PMID 11136230. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=14619.
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PDB gallery
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1zcb: Crystal structure of G alpha 13 in complex with GDP
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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| 3.6.3-4: ATPase |
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| 3.6.5: GTPase |
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Rho family of GTPases: Cdc42 (CDC42, TC10, TCL) • RhoUV (RhoU, RhoV) • Rac (Rac1, 2, 3, RhoG) • RhoBTB (1, 2) • RhoH • Rho (A, B, C) • Rnd (1, 2, 3) • RhoDF (RhoF, RhoD)
other: Ras ( HRAS, KRAS, NRAS) · Rab ( RAB23, RAB27) · Arf ( ARF6, SAR1B, ARL13B, ARL6) · Ran · Rheb · Rap
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B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
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