GLRB

Glycine receptor, beta

PDB rendering based on 1t3e.
Identifiers
Symbols GLRB;
External IDs OMIM: 138492 MGI: 95751 HomoloGene: 20224 IUPHAR: β GeneCards: GLRB Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 2743 14658
Ensembl ENSG00000109738 ENSMUSG00000028020
UniProt P48167 O54848
RefSeq (mRNA) NM_000824.4 NM_010298.5
RefSeq (protein) NP_000815.1 NP_034428.2
Location (UCSC) Chr 4:
158 – 158.09 Mb		 Chr 3:
80.65 – 80.72 Mb
PubMed search [1] [2]

Glycine receptor subunit beta is a protein that in humans is encoded by the GLRB gene.[1][2][3]

The inhibitory glycine receptor mediates postsynaptic inhibition in the spinal cord and other regions of the central nervous system. It is a pentameric receptor composed of alpha (GLRA1, MIM 138491; GLRA2, MIM 305990) and beta subunits.[supplied by OMIM][3]

Contents

See also

References

  1. ^ Milani N, Mulhardt C, Weber RG, Lichter P, Kioschis P, Poustka A, Becker CM (Oct 1998). "The human glycine receptor beta subunit gene (GLRB): structure, refined chromosomal localization, and population polymorphism". Genomics 50 (3): 341–5. doi:10.1006/geno.1998.5324. PMID 9676428. 
  2. ^ Handford CA, Lynch JW, Baker E, Webb GC, Ford JH, Sutherland GR, Schofield PR (Oct 1996). "The human glycine receptor beta subunit: primary structure, functional characterisation and chromosomal localisation of the human and murine genes". Brain Res Mol Brain Res 35 (1–2): 211–9. PMID 8717357. 
  3. ^ a b "Entrez Gene: GLRB glycine receptor, beta". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2743. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Cys-loop receptors
5-HT3 (A, B, C, D, E)
GABAA (α1, α2, α3, α4, α5, α6, β1, β2, β3, γ1, γ2, γ3, δ, ε, π, θ) · GABAA-ρ (ρ1, ρ2, ρ3)
α1 · α2 · α3 · α4 · β
monomers: α1 · α2 · α3 · α4 · α5 · α6 · α7 · α9 · α10 · β1 · β2 · β3 · β4 · δ · ε
pentamers: (α3)2(β4)3 · (α4)2(β2)3 · (α7)5 · (α1)2(β4)3 - Ganglion type · (α1)2β1δε - Muscle type
Zinc
Ionotropic glutamates
Ligand-gated only
AMPA (1, 2, 3, 4) · Kainate (1, 2, 3, 4, 5)
Voltage- and ligand-gated
NMDA (1, 2A, 2B, 2C, 2D, 3A, 3B, L1A, L1B)
‘Orphan’
GluD (δ1, δ2)
ATP-gated channels
P2X (1, 2, 3, 4, 5, 6, 7)
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)