GGTLA1
Gamma-glutamyltransferase 5 is an enzyme that in humans is encoded by the GGT5 gene.[1][2][3][4]
Gamma-glutamyltransferase-like activity 1 (GGTLA1) is a member of a gene family with at least 4 members (GGTLA1, GGTLA2, GGTLA3 and GGTLA4). The enzyme encoded by GGTLA1 is related to, but distinct from, gamma-glutamyl transpeptidase (GGT). The GGTLA1 enzyme consists of a heavy and a light chain and is able to hydrolyze the gamma-glutamyl moiety of glutathione. It converts leukotriene C4 to leukotriene D4, however, it doesn't convert synthetic substrates that are commonly used to assay GGT. Its amino acid sequence shows an overall similarity of 39.5% with human GGT.[4]
References
- ^ Heisterkamp N, Rajpert-De Meyts E, Uribe L, Forman HJ, Groffen J (Aug 1991). "Identification of a human gamma-glutamyl cleaving enzyme related to, but distinct from, gamma-glutamyl transpeptidase". Proc Natl Acad Sci U S A 88 (14): 6303–7. doi:10.1073/pnas.88.14.6303. PMC 52071. PMID 1676842. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=52071.
- ^ Morris C, Courtay C, Geurts van Kessel A, ten Hoeve J, Heisterkamp N, Groffen J (Apr 1993). "Localization of a gamma-glutamyl-transferase-related gene family on chromosome 22". Hum Genet 91 (1): 31–6. PMID 8095916.
- ^ Heisterkamp N, Groffen J, Warburton D, Sneddon TP (Apr 2008). "The human gamma-glutamyltransferase gene family". Hum Genet 123 (4): 321–32. doi:10.1007/s00439-008-0487-7. PMID 18357469.
- ^ a b "Entrez Gene: GGTLA1 gamma-glutamyltransferase-like activity 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2687.
Further reading
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Enoiu M, Aberkane H, Salazar JF, et al. (2000). "Evidence for the pro-oxidant effect of gamma-glutamyltranspeptidase-related enzyme.". Free Radic. Biol. Med. 29 (9): 825–33. doi:10.1016/S0891-5849(00)00370-1. PMID 11063908.
- Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
- Edelmann L, Pandita RK, Morrow BE (2000). "Low-copy repeats mediate the common 3-Mb deletion in patients with velo-cardio-facial syndrome.". Am. J. Hum. Genet. 64 (4): 1076–86. doi:10.1086/302343. PMC 1377832. PMID 10090893. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1377832.
- Potdar PD, Andrews KL, Nettesheim P, Ostrowski LE (1997). "Expression and regulation of gamma-glutamyl transpeptidase-related enzyme in tracheal cells.". Am. J. Physiol. 273 (5 Pt 1): L1082–9. PMID 9374738.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.